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  1. NTU Scholars
  2. 醫學院
  3. 醫學系
Please use this identifier to cite or link to this item: https://scholars.lib.ntu.edu.tw/handle/123456789/426662
Title: Biliary complications after liver transplantation: An 18-year single-center experience
Authors: Chang, Te I.
MING-CHIH HO 
YAO-MING WU 
PO-HUANG LEE 
REY-HENG HU 
Keywords: Bile leakage | Biliary stricture | Graft rejection | Liver transplantation | Percutaneous transhepatic cholangiography drainage;Bile leakage; Biliary stricture; Graft rejection; Liver transplantation; Percutaneous transhepatic cholangiography drainage
Issue Date: 1-Jan-2011
Journal Volume: 110
Journal Issue: 3
Source: Journal of the Formosan Medical Association
Abstract: 
Background/Purpose: Biliary complications remain a major weakness of liver transplantation. The purpose of this retrospective study was to determine risk factors associated with biliary complications after liver transplantation, and how they were managed. Methods: From October 1989 to December 2007, we collected all variables of interest in 253 consecutive liver transplant recipients at the National Taiwan University Hospital. Risk factors and the outcome of different treatments of the biliary complications were analyzed. Results: Forty-three (17.0%) of the 253 liver transplant patients developed biliary complications. Bile leakage and biliary stricture rate was 7.9% and 6.7%, respectively. By univariate analysis, risk factors associated with bile leakage were older age, cadaveric liver donation, and use of a T-tube. The only protecting factor against bile leakage was the use of a straight intrahepatic stent. Risk factors associated with biliary stricture were rejection and male sex. Multivariate analysis demonstrated that T-tube [odds ratio (OR) = 3.45] and older age group (OR=7.98) were the only independent risk factors for bile leakage, whereas graft rejection (OR=4.89) and male sex (OR=5.56) were the only independent risk factors for biliary stricture. Percutaneous transhepatic cholangiography drainage (37.2%) or computed-tomography-guided drainage (27.9%) was the most frequent initial treatment. Biliary event-free rate after initial treatment was 67.6% and 66.7% in the non-surgical and surgical group, respectively. Conclusion: The risk factors for bile leakage and biliary stricture were different due to different pathogenesis. Straight biliary stent in our series showed a protective effect against bile leakage. Non-surgical management can be a highly successful initial treatment, and surgery should be reserved for patients who have failed conservative treatment. © 2011 Elsevier & Formosan Medical Association.
URI: https://scholars.lib.ntu.edu.tw/handle/123456789/426662
ISSN: 09296646
DOI: 10.1016/S0929-6646(11)60029-6
SDG/Keyword: adult; article; bile duct obstruction; bile leakage; biliary tract disease; biliary tract drainage; cadaver donor; computer assisted tomography; donor; female; human; liver graft rejection; liver transplantation; major clinical study; male; percutaneous transhepatic cholangiography; postoperative complication; retrospective study; risk factor; stent; T tube; treatment outcome; university hospital
[SDGs]SDG3
Appears in Collections:醫學系

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臺大位居世界頂尖大學之列,為永久珍藏及向國際展現本校豐碩的研究成果及學術能量,圖書館整合機構典藏(NTUR)與學術庫(AH)不同功能平台,成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。

To permanently archive and promote researcher profiles and scholarly works, Library integrates the services of “NTU Repository” with “Academic Hub” to form NTU Scholars.

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開放取用是從使用者角度提升資訊取用性的社會運動,應用在學術研究上是透過將研究著作公開供使用者自由取閱,以促進學術傳播及因應期刊訂購費用逐年攀升。同時可加速研究發展、提升研究影響力,NTU Scholars即為本校的開放取用典藏(OA Archive)平台。(點選深入了解OA)

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