https://scholars.lib.ntu.edu.tw/handle/123456789/426867
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Wu Wen-Chau | en_US |
dc.contributor.author | YA-FANG CHEN | en_US |
dc.contributor.author | Tseng H.-M. | en_US |
dc.contributor.author | Yang S.-C. | en_US |
dc.contributor.author | My P.-C. | en_US |
dc.creator | Wu Wen-Chau;Ya-Fang Chen;Tseng H.-M;Yang S.-C;My P.-C. | - |
dc.date.accessioned | 2019-10-18T01:19:48Z | - |
dc.date.available | 2019-10-18T01:19:48Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 0938-7994 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84937641290&doi=10.1007%2fs00330-015-3655-x&partnerID=40&md5=67772949f51f84fcfc3eff9d2a8020f0 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/426867 | - |
dc.description.abstract | Objectives: To numerically and experimentally investigate the robustness of intravoxel incoherent motion (IVIM) magnetic resonance imaging in measuring perfusion indexes in the human brain. Methods: Eighteen healthy volunteers were imaged on a 3?T clinical system. Data of IVIM imaging (12 b-values ranging from 0 to 1000?s/mm2, 12 repetitions) were fitted with a bi-exponential model to extract blood volume fraction (f) and pseudo-diffusion coefficient (D*). The robustness of measurement was assessed by bootstrapping. Dynamic susceptibility contrast (DSC) imaging and arterial spin-labelling (ASL) imaging were performed for cross-modal comparison. Numerical simulations were performed to assess the accuracy and precision of f and D* estimates at varied signal-to-noise ratio (SNRb1000). Results: Based on our experimental setting (SNRb1000 ~ 30), the average error/variability is ~5?%/25?% for f and ~100?%/30?% for D* in gray matter, and ~10?%/50?% for f and ~300?%/60?% for D* in white matter. Correlation was found between f and DSC-derived cerebral blood volume in gray matter (r = 0.29 – 0.48 across subjects, p < 10-5), but not in white matter. No correlation was found between f-D*?product and ASL-derived cerebral blood flow. Conclusions: f may provide noninvasive measurement of cerebral blood volume, particularly in gray matter. D* has limited robustness and should be interpreted with caution. Key Points: ? A minimum SNRb1000of 30 is recommended for reliable IVIM imaging. ? f may provide noninvasive measurement of cerebral blood volume. ? f correlates with CBVDSCin gray matter. ? There is no correlation between fD* and CBFASL. ? D* has limited robustness and should be interpreted with caution. ? 2015, The Author(s). | - |
dc.language.iso | English | - |
dc.publisher | Springer Verlag | - |
dc.relation.ispartof | European Radiology | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | adult; analytical error; arterial spin labelling imaging; Article; bootstrapping; brain blood flow; brain blood volume; brain perfusion; brain region; brain scintiscanning; clinical assessment; contrast enhancement; controlled study; dynamic susceptibility contrast imaging; female; gray matter; human; human experiment; image analysis; intravoxel incoherent motion imaging; male; measurement accuracy; neuroimaging; normal human; nuclear magnetic resonance imaging; nuclear magnetic resonance scanner; priority journal; radiofrequency; radiological parameters; signal noise ratio; spin labeling; white matter; brain; brain circulation; evaluation study; feasibility study; motion; nuclear magnetic resonance imaging; physiology; procedures; prospective study; theoretical model; vascularization; young adult; Adult; Brain; Cerebrovascular Circulation; Feasibility Studies; Female; Gray Matter; Healthy Volunteers; Humans; Magnetic Resonance Imaging; Male; Models, Theoretical; Motion; Prospective Studies; Signal-To-Noise Ratio; Young Adult | - |
dc.title | Caveat of measuring perfusion indexes using intravoxel incoherent motion magnetic resonance imaging in the human brain | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1007/s00330-015-3655-x | - |
dc.identifier.pmid | 25693668 | - |
dc.identifier.scopus | 2-s2.0-84937641290 | - |
dc.relation.pages | 2485-2492 | - |
dc.relation.journalvolume | 25 | - |
dc.relation.journalissue | 8 | - |
item.fulltext | no fulltext | - |
item.openairetype | journal article | - |
item.languageiso639-1 | English | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | Medical Device and Imaging | - |
crisitem.author.dept | Radiology | - |
crisitem.author.dept | Biomedical Electronics and Bioinformatics | - |
crisitem.author.dept | Master's Program in Smart Medicine and Health Informatics (SMARTMHI) | - |
crisitem.author.dept | Radiology | - |
crisitem.author.dept | Medical Imaging-NTUH | - |
crisitem.author.orcid | 0000-0002-4040-2771 | - |
crisitem.author.orcid | 0000-0003-2995-9189 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Electrical Engineering and Computer Science | - |
crisitem.author.parentorg | International College | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 醫療器材與醫學影像研究所 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。