https://scholars.lib.ntu.edu.tw/handle/123456789/431125
標題: | Omega-3 fatty acids-enriched fish oil activates AMPK/PGC-1α signaling and prevents obesity-related skeletal muscle wasting | 作者: | SHING-HWA LIU Chiu C.-Y. Wang L.-P. Chiang M.-T. |
關鍵字: | AMP-activated protein kinase; Fish oil; Obesity; Skeletal muscle wasting | 公開日期: | 2019 | 出版社: | MDPI AG | 卷: | 17 | 期: | 6 | 來源出版物: | Marine Drugs | 摘要: | Obesity is known to cause skeletal muscle wasting. This study investigated the effect and the possible mechanism of fish oil on skeletal muscle wasting in an obese rat model. High-fat (HF) diets were applied to induce the defects of lipid metabolism in male Sprague-Dawley rats with or without substitution of omega-3 fatty acids-enriched fish oil (FO, 5%) for eight weeks. Diets supplemented with 5% FO showed a significant decrease in the final body weight compared to HF diet-fed rats. The decreased soleus muscle weights in HF diet-fed rats could be improved by FO substitution. The decreased myosin heavy chain (a muscle thick filament protein) and increased FOXO3A and Atrogin-1 (muscle atrophy-related proteins) protein expressions in soleus muscles of HF diet-fed rats could also be reversed by FO substitution. FO substitution could also significantly activate adenosine monophosphate (AMP)-activated protein kinase (AMPK) phosphorylation, peroxisome-proliferator-activated receptor-γ (PPARγ) coactivator 1α (PGC-1α), and PPARγ protein expression and lipoprotein lipase (LPL) mRNA expression in soleus muscles of HF diet-fed rats. These results suggest that substitution of FO exerts a beneficial improvement in the imbalance of lipid and muscle metabolisms in obesity. AMPK/PGC-1α signaling may play an important role in FO-prevented obesity-induced muscle wasting. ? 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85068864636&doi=10.3390%2fmd17060380&partnerID=40&md5=ba9389a5d924452cacd6ff4bd82086b1 https://scholars.lib.ntu.edu.tw/handle/123456789/431125 |
ISSN: | 1660-3397 | DOI: | 10.3390/md17060380 | SDG/關鍵字: | atrogin 1; fish oil; hydroxymethylglutaryl coenzyme A reductase kinase; lipid; lipoprotein lipase; messenger RNA; myosin heavy chain; omega 3 fatty acid; peroxisome proliferator activated receptor gamma; peroxisome proliferator activated receptor gamma coactivator 1alpha; transcription factor FKHRL1; fish oil; hydroxymethylglutaryl coenzyme A reductase kinase; omega 3 fatty acid; peroxisome proliferator activated receptor gamma coactivator 1alpha; Ppargc1a protein, rat; animal experiment; animal model; animal tissue; Article; body weight; controlled study; diet supplementation; enzyme phosphorylation; infant; lipid diet; lipid metabolism; male; muscle atrophy; muscle metabolism; nonhuman; obesity; prophylaxis; protein expression; rat; signal transduction; soleus muscle; adverse event; animal; drug effect; metabolism; muscle atrophy; obesity; signal transduction; skeletal muscle; Sprague Dawley rat; AMP-Activated Protein Kinases; Animals; Diet, High-Fat; Fatty Acids, Omega-3; Fish Oils; Lipid Metabolism; Male; Muscle, Skeletal; Muscular Atrophy; Obesity; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Rats; Rats, Sprague-Dawley; Signal Transduction |
顯示於: | 毒理學研究所 |
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