https://scholars.lib.ntu.edu.tw/handle/123456789/431175
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Wu S.-Y. | en_US |
dc.contributor.author | Yan M.-D. | en_US |
dc.contributor.author | Wu A.T.H. | en_US |
dc.contributor.author | Yuan K.S.-P. | en_US |
dc.contributor.author | SHING-HWA LIU | en_US |
dc.creator | Wu S.-Y.;Yan M.-D.;Wu A.T.H.;Yuan K.S.-P.;Shing-Hwa Liu | - |
dc.date.accessioned | 2019-11-12T07:36:31Z | - |
dc.date.available | 2019-11-12T07:36:31Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 1837-9664 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85006963777&doi=10.7150%2fjca.15703&partnerID=40&md5=c66e7e6528097e139db347beed90d09b | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/431175 | - |
dc.description.abstract | In this study, we observed that brown seaweed fucoidan inhibited human breast cancer progression by upregulating microRNA (miR)-29c and downregulating miR-17-5p, thereby suppressing their target genes, a disintegrin and metalloproteinase 12 (ADAM12) and phosphatase and tensin homolog (PTEN), respectively. Moreover, fucoidan reduced the luciferase activity of 3'-untranslated region reporter; treatment of cells with the miR-29c mimic or miR-17-5p inhibitor also produced similar results. These effects of fucoidan inhibited the epithelial-mesenchymal transition in breast cancer cells, as evidenced by an increase in E-cadherin and a drop in N-cadherin, and inhibited breast cancer cell survival, as evidenced by the activation of the phosphoinositide 3-kinase/Akt pathway. Taken together, these findings demonstrate that fucoidan inhibits breast cancer progression by regulating the miR-29c/ADAM12 and miR-17-5p/PTEN axes. Fucoidan is a potential chemopreventive/chemotherapeutic agent for breast cancer. ? Ivyspring International Publisher. | - |
dc.language.iso | English | - |
dc.publisher | Ivyspring International Publisher | - |
dc.relation.ispartof | Journal of Cancer | - |
dc.subject | ADAM12; Breast cancer cells; Fucoidan; MiR-17-5p; MiR-29c; PTEN | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | ADAM protein; adam12 protein; antineoplastic agent; fucoidin; luciferase; microRNA; microRNA 17 5p; microRNA 29c; nerve cell adhesion molecule; phosphatidylinositol 3 kinase; phosphatidylinositol 3,4,5 trisphosphate 3 phosphatase; unclassified drug; uvomorulin; 3' untranslated region; antineoplastic activity; Article; breast cancer; cancer inhibition; cell survival; chemoprophylaxis; controlled study; down regulation; drug inhibition; enzyme activation; enzyme activity; epithelial mesenchymal transition; gene repression; gene targeting; human; human cell; MCF 7 cell line; MDA MB 231 cell line; reporter gene; seaweed; upregulation | - |
dc.title | Brown Seaweed Fucoidan Inhibits Cancer Progression by Dual Regulation of mir-29c/ADAM12 and miR-17-5p/PTEN Axes in Human Breast Cancer Cells | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.7150/jca.15703 | - |
dc.identifier.scopus | 2-s2.0-85006963777 | - |
dc.relation.pages | 2408-2419 | - |
dc.relation.journalvolume | 7 | - |
dc.relation.journalissue | 15 | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.languageiso639-1 | English | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
crisitem.author.dept | Toxicology | - |
crisitem.author.orcid | 0000-0002-9976-1197 | - |
crisitem.author.parentorg | College of Medicine | - |
顯示於: | 毒理學研究所 |
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