https://scholars.lib.ntu.edu.tw/handle/123456789/431452
Title: | Connective tissue growth factor decreases mitochondrial metabolism through ubiquitin-mediated degradation of mitochondrial transcription factor A in oral squamous cell carcinoma | Authors: | WANG-TSO LEE Li, Yue-Ju Wu, Shi-Bei Yang, Cheng-Ning Wu, Tai-Sheng Wei, Yau-Huei Deng, Yi-Ting |
Keywords: | CTGF; Metabolism; Mitochondrion; OSCC; mtTFA | Issue Date: | Mar-2018 | Publisher: | ELSEVIER TAIWAN | Journal Volume: | 117 | Journal Issue: | 3 | Start page/Pages: | 212 | Source: | Journal of the Formosan Medical Association = Taiwan yi zhi | Abstract: | Deregulation of metabolic pathways is one of the hallmarks of cancer progression. Connective tissue growth factor (CTGF/CCN2) acts as a tumor suppressor in oral squamous cell carcinoma (OSCC). However, the role of CTGF in modulating cancer metabolism is still unclear. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/431452 | ISSN: | 0929-6646 | DOI: | 10.1016/j.jfma.2017.04.003 | SDG/Keyword: | adenosine triphosphate; benzyloxycarbonylleucylleucylleucinal; connective tissue growth factor; mitochondrial DNA; mitochondrial transcription factor A; short hairpin RNA; ubiquitin; ubiquitinated protein; connective tissue growth factor; DNA binding protein; mitochondrial protein; mitochondrial transcription factor A; transcription factor; ubiquitin; acidification; Article; cell invasion; cell migration; copy number variation; glycolysis; immunoprecipitation; mitochondrial biogenesis; mitochondrial respiration; mouth squamous cell carcinoma; oxygen consumption; protein expression; real time polymerase chain reaction; SAS cell line; Western blotting; human; metabolism; mitochondrion; mouth tumor; physiology; squamous cell carcinoma; tumor cell line; Carcinoma, Squamous Cell; Cell Line, Tumor; Connective Tissue Growth Factor; DNA-Binding Proteins; Humans; Mitochondria; Mitochondrial Proteins; Mouth Neoplasms; Transcription Factors; Ubiquitin |
Appears in Collections: | 臨床牙醫學研究所 |
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