https://scholars.lib.ntu.edu.tw/handle/123456789/432017
DC Field | Value | Language |
---|---|---|
dc.contributor.author | B.-S. Yip | en_US |
dc.contributor.author | Lai, Tzu-Hsien; Wang, Wen-Fu | en_US |
dc.creator | Lai, Tzu-Hsien; Wang, Wen-Fu;B.-S. Yip | - |
dc.date.accessioned | 2019-11-21T08:54:32Z | - |
dc.date.available | 2019-11-21T08:54:32Z | - |
dc.date.issued | 2016 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84962366928&doi=10.2147%2fPPA.S95271&partnerID=40&md5=78a878d97bb23d8b34c77a2333a221b4 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/432017 | - |
dc.description.abstract | Purpose: Among the medications approved for Alzheimer’s disease (AD), rivastigmine is the only one available as transdermal patch. The aim of this study was to evaluate compliance and caregivers’ preference with oral and transdermal (rivastigmine) monotherapy in patients with mild-to-moderate AD from Taiwan. Methods: Real-world Evaluation of Compliance And Preference in Alzheimer’s disease treatment (RECAP) in Taiwan was a prospective, noninterventional, observational study with a 24-week (±8 weeks) observational period for each participant. Eligible patients were grouped into one of the two treatment cohorts based on the baseline AD therapy: oral (donepezil, galantamine, rivastigmine, or memantine) or transdermal (rivastigmine patch). The primary end points were caregiver preference and caregiver assessment of patients’ compliance to the current medication (oral or transdermal medication) at Week 24 (end of the study). Safety was assessed by recording any adverse events. Results: A total of 301 patients (age: 77.6±7.19 years) were enrolled from nine centers in Taiwan, of whom 138 (45.8%) patients were in the transdermal monotherapy cohort. Caregivers of patients who were exposed to both forms of therapies demonstrated a higher preference for transdermal rivastigmine monotherapy than the oral monotherapy (82.4% [n=61] versus 17.6% [n=13], P<0.0001); for patients treated with only one therapy, the caregivers’ preference was significantly in favor of the treatment to which the patient was exposed (both P<0.0001). In both cohorts, patients showed good compliance, with an overall score of 8.65±1.38 on an 11-point scale. Of 301 enrolled patients, 102 (33.9%) reported at least one adverse event during the study (51 patients each in the two cohorts). Conclusion: With the higher caregiver preference and a good patient compliance, the transdermal rivastigmine patch is a suitable treatment choice for patients with mild-to-moderate AD, especially for patients intolerant to oral therapies. ? 2016 Lai et al. | - |
dc.relation.ispartof | Patient Preference and Adherence | - |
dc.subject | Alzheimer’s disease; Caregiver preference; Cholinesterase inhibitors; Observational study; Patient compliance; Rivastigmine | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | donepezil; galantamine; memantine; rivastigmine; aged; Alzheimer disease; Article; attitude to health; caregiver preference; clinical evaluation; cohort analysis; controlled study; decreased appetite; disease severity; dizziness; drug preference; drug safety; drug withdrawal; female; gastrointestinal disease; high risk population; human; insomnia; major clinical study; male; medication compliance; metabolic disorder; monotherapy; nausea; nutritional disorder; observational study; outcome assessment; prospective study; pruritus; rash; sex difference; skin disease; subcutaneous tissue disorder; Taiwan; vomiting | - |
dc.title | Real-world evaluation of compliance and preference in Alzheimer's disease treatment: An observational study in Taiwan | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.2147/PPA.S95271 | - |
dc.relation.pages | 383-390 | - |
dc.relation.journalvolume | 10 | - |
item.fulltext | no fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.cerifentitytype | Publications | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
crisitem.author.dept | Neurology-NTUHHC | - |
crisitem.author.orcid | 0000-0001-7942-8293 | - |
crisitem.author.parentorg | NTU Hsin-Chu Hospital | - |
Appears in Collections: | 醫學院附設醫院 (臺大醫院) |
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