https://scholars.lib.ntu.edu.tw/handle/123456789/434058
標題: | Cardiac allograft vasculopathy compared by intravascular ultrasound sonography: Everolimus to mycophenolate mofetil - One single-center experience | 作者: | NAI-KUAN CHOU CHYI-FENG JAN NAI-HSIN CHI CHII-MING LEE I-HUI WU SHU-CHIEN HUANG YIH-SHARNG CHEN HSI-YU YU Tsao C.-I. Ko W.-J. Chu S.-H. SHOEI-SHEN WANG |
公開日期: | 五月-2012 | 卷: | 44 | 期: | 4 | 起(迄)頁: | 897 | 來源出版物: | Transplantation Proceedings | 摘要: | Cardiac allograft vasculopathy (CAV) remains one of the leading causes of late graft failure and death. Cyclosporine microemulsion Neoral (CsA) had been used in heart transplantation (HTx) recipients. Meanwhile, Everolimus (EVL; Certican, Norvatis Pharmaceuticals; Basel, Switzerland) or mycophenolate mofetil (MMF) have been combined with CsA for maintenance treatment. We compared atherosclerosis in HTx patients showing CAV by intravascular ultrasound (IVUS) in two groups: the CE who received CsA, EVL, and steroid versus the CM group, who received CsA, MMF, and steroid. Materials and Methods: We explored IVUS parameters such as plaque thickness (PT), lumen circumference (LC), media adventitial circumference, lumen diameter (LD), and media adventitial diameter to characterize the atherosclerosis among CE versus CM groups. Results: In this study, both the CE and CM groups showed increased plaque thickening in the first year posttransplantation (P <.05). However, MMF significantly reduced LC and LD (P <.05) Upon multivariate linear regression analysis, the CE group seemed to show less effect on the maximal difference in PT between 2 and 12 months after adjusting for age at transplantation and gender (P <.05). There was no acute clinical adverse event of CAV reported in either both group during the follow-up. The atherosclerosis of CAV revealed by LC, LDmax, and LDmin was significantly less among patients treated with CE than CM. Conclusion: These results suggested that everolimus-treated patients showed benefits compared with MMF-treated subjects as extrapolated from these IVUS data. ? 2012 Elsevier Inc. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84860705686&doi=10.1016%2fj.transproceed.2012.03.041&partnerID=40&md5=c2b3b7c022489f11f8ec8ee2b904219c https://scholars.lib.ntu.edu.tw/handle/123456789/434058 |
ISSN: | 0041-1345 | DOI: | 10.1016/j.transproceed.2012.03.041 | SDG/關鍵字: | cyclosporin A; everolimus; mycophenolic acid 2 morpholinoethyl ester; steroid; adult; age; aged; atherosclerotic plaque; cardiac allograft vasculopathy; cardiac patient; clinical article; conference paper; controlled study; echography; female; follow up; gender; heart transplantation; human; intravascular ultrasound; male; multiple linear regression analysis; priority journal; Adult; Aged; Coronary Artery Disease; Cyclosporine; Drug Therapy, Combination; Female; Heart Transplantation; Humans; Immunosuppressive Agents; Linear Models; Male; Middle Aged; Multivariate Analysis; Mycophenolic Acid; Predictive Value of Tests; Risk Assessment; Risk Factors; Sirolimus; Steroids; Taiwan; Time Factors; Treatment Outcome; Ultrasonography, Interventional |
顯示於: | 醫學系 |
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