https://scholars.lib.ntu.edu.tw/handle/123456789/434126
Title: | Extracorporeal membrane oxygenation rescue for cardiopulmonary resuscitation in pediatric patients | Authors: | SHU-CHIEN HUANG EN-TING WU YIH-SHARNG CHEN CHUNG-I CHANG ING-SH CHIU SHOEI-SHEN WANG Lin F.-Y. Ko W.-J. |
Issue Date: | 2008 | Publisher: | Lippincott Williams and Wilkins | Journal Volume: | 36 | Journal Issue: | 5 | Start page/Pages: | 1607-1613 | Source: | Critical Care Medicine | Abstract: | OBJECTIVE: To describe survival and neurologic outcome and identify the factors associated with survival among pediatric patients following extracorporeal cardiopulmonary resuscitation (ECPR) for in-hospital cardiac arrest. DESIGN: Retrospective study. SETTING: A university-affiliated tertiary care hospital. PATIENTS: Eligible patients were ?18 yrs of age and received extracorporeal membrane oxygenation during active cardiopulmonary resuscitation for in-hospital cardiac arrest. INTERVENTIONS: Extracorporeal membrane oxygenation (ECMO) during active cardiopulmonary resuscitation. MEASUREMENTS AND MAIN RESULTS: The primary outcome was survival to hospital discharge. The secondary outcome was neurologic status after ECPR at hospital discharge and late follow-up. Good neurologic outcome was defined as Pediatric Cerebral Performance Categories 1, 2, and 3. Continuous variables were expressed as medians (interquartile range). We prospectively defined the early cohort (January 1999 to December 2001) and late cohort (January 2002 to January 2006) and compared the survival rates. We identified 27 ECPR events. The survival rate to hospital discharge was 41% (11 of 27). The nonsurvivors had higher pre-cardiopulmonary resuscitation serum lactate levels (14 [10.2-19.6] mmol/L vs. 8.5 [4.4-12.6] mmol/L, p < .01), longer durations of cardiopulmonary resuscitation (60 [37-81] mins vs. 45 [25-50] mins, p < .05) with longer activating time for ECMO (12.5 [7.5-33.8] mins vs. 5 [0-10] mins, p < .01), and more renal failure after ECPR (68% [11 of 16] vs. 9% [1 of 11], p < .01). The survival rate of the late cohort was better than that of the early cohort (58% [11 of 19] vs. 0% [0 of 8], p < .05). By exact multiple logistic regression analysis, the early cohort and renal failure after ECPR were two independent risk factors for mortality. Among the 11 survivors, ten had good neurologic outcomes. CONCLUSIONS: ECPR successfully rescued some pediatric patients who failed rescue with conventional in-hospital CPR. Good neurologic outcomes were achieved in the majority of the survivors. Early cohort and post-ECPR renal failure were associated with mortality. ? 2008 Lippincott Williams & Wilkins, Inc. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-42949115926&doi=10.1097%2fCCM.0b013e318170b82b&partnerID=40&md5=c765c4e445ff3096fe03070a980825b8 https://scholars.lib.ntu.edu.tw/handle/123456789/434126 |
ISSN: | 0090-3493 | DOI: | 10.1097/CCM.0b013e318170b82b | SDG/Keyword: | lactic acid; adolescent; article; cannula; child; child care; clinical article; extracorporeal oxygenation; female; follow up; heart arrest; hospital discharge; hospitalization; human; infant; intensive care unit; kidney failure; lactate blood level; male; mortality; neurologic disease; newborn; priority journal; resuscitation; risk factor; survival rate; tertiary health care; treatment duration; treatment outcome |
Appears in Collections: | 醫學系 |
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