https://scholars.lib.ntu.edu.tw/handle/123456789/434339
Title: | Cytoplasmic CD24 expression is a novel prognostic factor in diffuse-type gastric adenocarcinoma | Authors: | Chou Y.-Y. YUNG-MING JENG Lee T.-T. Hu F.-C. Kao H.-L. WEI-CHOU LIN Lai P.-L. REY-HENG HU RAY-HWANG YUAN |
Issue Date: | 2007 | Journal Volume: | 14 | Journal Issue: | 10 | Start page/Pages: | 2748-2758 | Source: | Annals of Surgical Oncology | Abstract: | Background: CD24, a mucin like cell surface adhesion molecule and a ligand for P-selectin, has been reported as a prognostic factor in a variety of human cancers. However, the role of CD24 in gastric adenocarcinoma remains largely unknown. Methods: The expression pattern of CD24 in 103 gastric adenocarcinomas (31 diffuse type, 60 intestinal type, and 12 mixed type) was analyzed by immunohistochemistry. Results: Cytoplasmic CD24 expression occurred in 50% of the gastric adenocarcinoma patients and was associated with high-stage tumor (Stage III-IV, P = .023), serosal invasion (SI, P = .010), lymphovascular invasion (LVI, P = .039), and lower 10-year survival (P = .0238). The CD24 staining pattern was different in intestinal and diffuse-type gastric adenocarcinomas. However, the tumor thrombi in lymphovascular spaces exhibited strong cytoplasmic CD24 expression in both types. Further analysis showed that cytoplasmic CD24 expression was, in fact, correlated with high-stage tumor, SI, LVI, and lower 10-year survival significantly (P = .020, P = .007, P = .018, P = .0285, respectively) in diffuse-type gastric adenocarcinoma. Moreover, multivariate analysis showed that cytoplasmic CD24 expression was an independent risk factor of SI and LVI respectively (P = .0083 and P = .0019), and thus it contributed to high-stage tumor and poor patient survival in diffuse- or mixed-type gastric adenocarcinoma. Conclusions: Cytoplasmic expression of CD24 was associated with invasiveness and poorer prognosis and can serve as a novel target for prognostic prediction and adjuvant treatment of patients with diffuse-type gastric adenocarcinoma after tumor resection. ? 2007 The Society of Surgical Oncology, Inc. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-34648820462&doi=10.1245%2fs10434-007-9501-x&partnerID=40&md5=292c389cb29549a68c31fcce4bf015f6 https://scholars.lib.ntu.edu.tw/handle/123456789/434339 |
ISSN: | 1068-9265 | DOI: | 10.1245/s10434-007-9501-x | SDG/Keyword: | CD24 antigen; adult; aged; article; cancer grading; cancer invasion; cancer patient; cancer risk; cancer survival; cell membrane; female; human; human tissue; immunohistochemistry; lymph node metastasis; major clinical study; male; multivariate analysis; prognosis; protein determination; protein expression; risk factor; stomach adenocarcinoma; survival rate; survival time; tumor thrombus; Adenocarcinoma; Adult; Aged; Aged, 80 and over; Antigens, CD24; Cytoplasm; Female; Humans; Immunoenzyme Techniques; Lymph Nodes; Lymphatic Metastasis; Male; Middle Aged; Neoplasm Invasiveness; Neoplasm Staging; Prognosis; Serous Membrane; Stomach; Stomach Neoplasms; Survival Analysis; Tumor Markers, Biological |
Appears in Collections: | 醫學系 |
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