https://scholars.lib.ntu.edu.tw/handle/123456789/434662
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | MENG-KUN TSAI | en_US |
dc.contributor.author | REY-HENG HU | en_US |
dc.contributor.author | Lee C.-J. | en_US |
dc.contributor.author | PO-HUANG LEE | en_US |
dc.creator | Meng-Kun Tsai;Hu R.-H.;Lee C.-J.;Lee P.-H. | - |
dc.date.accessioned | 2019-12-04T02:00:17Z | - |
dc.date.available | 2019-12-04T02:00:17Z | - |
dc.date.issued | 2002 | - |
dc.identifier.issn | 0929-6646 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0036767640&partnerID=40&md5=fabd5be4b623582b072c05adc0a0cb6f | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/434662 | - |
dc.description.abstract | Background and Purpose: Mycophenolate mofetil (MMF) in combination with cyclosporine or tacrolimus prevents acute rejection and chronic allograft failure in renal transplantation in Western countries. We began to add low-dose MMF to primary cyclosporine immunosuppressive therapy in renal transplantation at the Department of Surgery of National Taiwan University Hospital in 1998. This study compared low-dose MMF to conventional therapy in Taiwanese renal transplant recipients. Methods: This retrospective cohort study determined the efficacy of low-dose MMF therapy (1 g/day in divided doses). A total of 275 cases with allograft kidney transplants were grouped according to whether they received transplants before or after the adoption of MMF therapy (Period I: 1987-1993; Period II: 1994-1997; Period III: 1998-September 2000). The prognostic significance of MMF therapy and graft and patient survival rate in each time period were assessed. Results: The 18-month graft survival rate was 84.9% in Period I, 86.3% in Period II, and 91.9% in Period III. The 5-year graft survival rates in Periods I and II were 69.3% and 76.6%, respectively. Acute rejection was significantly detrimental to graft survival (p = 0.048), while MMF therapy was significantly advantageous to graft survival (p = 0.015); treatment when MMF was available was also significantly associated with better graft survival (p = 0.043). There was a negative correlation between acute rejection and graft survival (p = 0.035); MMF therapy produced a protective effect on graft survival independent of acute rejection (p = 0.010). Conclusion: Low-dose MMF therapy significantly improved graft survival after renal transplantation in Taiwanese kidney allograft recipients. | en_US |
dc.relation.ispartof | Journal of the Formosan Medical Association | en_US |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | azathioprine; cyclosporin A; immunosuppressive agent; lamivudine; lymphocyte antibody; methylprednisolone; mycophenolic acid 2 morpholinoethyl ester; prednisolone; tacrolimus; acute graft rejection; adolescent; adult; aged; allergy; article; cancer; cohort analysis; controlled study; diarrhea; dose response; drug blood level; drug efficacy; drug pulse therapy; female; graft survival; hepatitis B; human; immunosuppressive treatment; kidney allograft; kidney allograft rejection; kidney failure; kidney transplantation; major clinical study; male; prognosis; recipient; retina degeneration; retrospective study; school child; septicemia; surgical ward; Taiwan; university hospital; virus reactivation; Acute Disease; Adolescent; Adult; Aged; Analysis of Variance; Child; Cyclosporine; Drug Therapy, Combination; Female; Graft Rejection; Humans; Immunosuppressive Agents; Kidney Transplantation; Male; Middle Aged; Mycophenolic Acid; Proportional Hazards Models; Retrospective Studies; Survival Analysis; Taiwan | - |
dc.title | Efficacy of low-dose mycophenolate mofetil therapy for Taiwanese renal transplantation patients receiving primary cyclosporine immunosuppression | en_US |
dc.type | journal article | en |
dc.identifier.pmid | 12645188 | - |
dc.identifier.scopus | 2-s2.0-0036767640 | - |
dc.relation.pages | 616-621 | en_US |
dc.relation.journalvolume | 101 | en_US |
dc.relation.journalissue | 9 | en_US |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
crisitem.author.dept | Surgery-NTUH | - |
crisitem.author.dept | Surgery | - |
crisitem.author.dept | NTU Hsin-Chu Hospital | - |
crisitem.author.dept | Surgery | - |
crisitem.author.dept | Surgery-NTUH | - |
crisitem.author.dept | Surgery | - |
crisitem.author.dept | Surgery-NTUH | - |
crisitem.author.orcid | 0000-0002-2962-8913 | - |
crisitem.author.orcid | 0000-0001-6709-031X | - |
crisitem.author.orcid | 0000-0001-5831-035X | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital Hsin-Chu Branch | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 醫學系 |
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