https://scholars.lib.ntu.edu.tw/handle/123456789/434905
標題: | Liver injury in patients with DRESS: A clinical study of 72 cases | 作者: | Lin, I-Chun HUNG-CHIH YANG Strong, Carol Yang, Che-Wen YUNG-TSU CHO Chen, Kai-Lung CHIA-YU CHU |
關鍵字: | Drug eruption;Drug reaction with eosinophilia and systemic symptoms;Drug-induced hypersensitivity syndrome;Interface change;Liver injury | 公開日期: | 1-六月-2015 | 出版社: | Mosby Inc. | 卷: | 72 | 期: | 6 | 起(迄)頁: | 984 | 來源出版物: | Journal of the American Academy of Dermatology | 摘要: | Background Drug reaction with eosinophilia and systemic symptoms (DRESS) is a syndrome involving multiple systems. Liver injury is the most common visceral manifestation. Objective The purpose of this study was to investigate the types of liver injury and factors associated with DRESS. Methods A retrospective cohort study was conducted in Taiwan using a DRESS database compiled from December 2000 to March 2013. Results Seventy-two cases were included in this study. Among them, 62 (86.1%) cases involved liver injury, 6 of which (9.7%) were liver injury before skin presentation. The distribution of liver injury patterns at initial presentation was 23 cholestatic type (37.1%), 17 mixed type (27.4%), and 12 hepatocellular type (19.4%). Patients with hepatocellular-type injuries were younger, with a median age of 31.5 (P =.044). Individuals with liver function results more than 10 times the upper limit were more likely to have fever (P =.026), took more time to recover, and had fewer eosinophils in the dermis (P =.002). Limitations The study was a retrospective cohort study with limited cases. Conclusions Liver injury is common in DRESS and frequently associated with atypical lymphocytosis. The cholestatic type is the most common type. Patients with cholestatic-type injuries were older and more frequently had interface changes in skin pathology. ? 2015 American Academy of Dermatology, Inc. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84929654524&doi=10.1016%2fj.jaad.2015.02.1130&partnerID=40&md5=3872674b220194f49fda829737785bc3 https://scholars.lib.ntu.edu.tw/handle/123456789/434905 |
ISSN: | 0190-9622 | DOI: | 10.1016/j.jaad.2015.02.1130 | SDG/關鍵字: | allopurinol; anticonvulsive agent; dapsone; phenytoin; sulfonamide; sulfone; adult; Article; disease association; DRESS syndrome; eosinophil count; eosinophilia; female; fever; human; human cell; intrahepatic cholestasis; liver function; liver injury; lymphocytosis; major clinical study; male; priority journal; retrospective study; skin manifestation; Taiwan; age distribution; aged; cohort analysis; comorbidity; drug effects; Drug Hypersensitivity Syndrome; Drug-Induced Liver Injury; factual database; liver; liver function test; middle aged; nonparametric test; prevalence; prognosis; severity of illness index; sex ratio; Adult; Age Distribution; Aged; Cohort Studies; Comorbidity; Databases, Factual; Drug Hypersensitivity Syndrome; Drug-Induced Liver Injury; Female; Humans; Liver; Liver Function Tests; Male; Middle Aged; Prevalence; Prognosis; Retrospective Studies; Severity of Illness Index; Sex Distribution; Statistics, Nonparametric; Taiwan |
顯示於: | 醫學系 |
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