https://scholars.lib.ntu.edu.tw/handle/123456789/434926
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Chang C.-C. | en_US |
dc.contributor.author | Yang M.-H. | en_US |
dc.contributor.author | BEEN-REN LIN | en_US |
dc.contributor.author | Chen S.-T. | en_US |
dc.contributor.author | SZU-HUA PAN | en_US |
dc.contributor.author | Hsiao M. | en_US |
dc.contributor.author | Lai T.-C. | en_US |
dc.contributor.author | SZE-KWAN LIN | en_US |
dc.contributor.author | YUNG-MING JENG | en_US |
dc.contributor.author | CHIA-YU CHU | en_US |
dc.contributor.author | Chen R.-H. | en_US |
dc.contributor.author | PAN-CHYR YANG | en_US |
dc.contributor.author | Eugene Chin Y. | en_US |
dc.contributor.author | Kuo M.-L. | en_US |
dc.creator | Chang C.-C.;Yang M.-H.;Lin B.-R.;Chen S.-T.;Pan S.-H.;Hsiao M.;Lai T.-C.;Lin S.-K.;Jeng Y.-M.;Chia-Yu Chu;Chen R.-H.;Yang P.-C.;Eugene Chin Y.;Kuo M.-L. | - |
dc.date.accessioned | 2019-12-04T08:43:50Z | - |
dc.date.available | 2019-12-04T08:43:50Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 1350-9047 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84873709117&doi=10.1038%2fcdd.2012.136&partnerID=40&md5=c42b79cb9310d665d0ddb133621eb505 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/434926 | - |
dc.description.abstract | CCN family protein 2 (CCN2), also known as connective tissue growth factor, is a secreting protein that modulates multiple cellular events. We previously demonstrated the metastasis-suppressive effect of CCN2 in lung cancer cells. In this study, we investigate the role of CCN2 in anoikis, a form of programmed cell death that is critical in suppressing cancer metastasis. CCN2 binds to the epidermal growth factor receptor (EGFR) and triggers ubiquitination by inhibiting the formation of the β-pix/Cbl complex, resulting in the degradation of EGFR. Binding of CCN2 to EGFR suppresses the phosphorylation of c-Src and extracellular signal-regulated kinase but increases the expression of death-associated protein kinase, which leads to anoikis. Overall, our findings provide evidence validating the use of CCN2 as an anti-metastatic therapy in lung cancer patients, and prospect a potential therapeutic synergy between CCN2 and the anti-EGFR antibody for the treatment of lung cancer. ? 2013 Macmillan Publishers Limited All rights reserved. | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.ispartof | Cell Death and Differentiation | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | Cbl protein; cetuximab; connective tissue growth factor; death associated protein kinase; epidermal growth factor receptor; mitogen activated protein kinase; p21 activated kinase interacting exchange factor; phosphatidylinositol 3 kinase; protein; protein kinase B; protein tyrosine kinase; unclassified drug; anoikis; article; cancer cell; carboxy terminal sequence; complex formation; controlled study; drug potentiation; human; human cell; lung cancer; metastasis inhibition; molecular model; priority journal; protein binding; protein degradation; protein domain; protein function; protein phosphorylation; ubiquitination | - |
dc.title | CCN2 inhibits lung cancer metastasis through promoting DAPK-dependent anoikis and inducing EGFR degradation | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1038/cdd.2012.136 | - |
dc.identifier.pmid | 23175185 | - |
dc.identifier.scopus | 2-s2.0-84873709117 | - |
dc.relation.pages | 443-455 | - |
dc.relation.journalvolume | 20 | - |
dc.relation.journalissue | 3 | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
crisitem.author.dept | Surgery-NTUH | - |
crisitem.author.dept | Surgery | - |
crisitem.author.dept | Medical Genomics and Proteomics | - |
crisitem.author.dept | Dentistry | - |
crisitem.author.dept | School of Dentistry | - |
crisitem.author.dept | Dentistry-NTUH | - |
crisitem.author.dept | Pathology | - |
crisitem.author.dept | Pathology-NTUH | - |
crisitem.author.dept | Dermatology | - |
crisitem.author.dept | Dermatology-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Clinical Medicine | - |
crisitem.author.dept | Clinical Pharmacy | - |
crisitem.author.dept | Oncology | - |
crisitem.author.dept | Biomedical Electronics and Bioinformatics | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.orcid | 0000-0001-8354-1758 | - |
crisitem.author.orcid | 0000-0002-0138-0434 | - |
crisitem.author.orcid | 0000-0002-7969-0280 | - |
crisitem.author.orcid | 0000-0002-3878-4491 | - |
crisitem.author.orcid | 0000-0002-9370-3279 | - |
crisitem.author.orcid | 0000-0001-6330-6048 | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Electrical Engineering and Computer Science | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
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