https://scholars.lib.ntu.edu.tw/handle/123456789/435674
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Chen Y.-T. | en_US |
dc.contributor.author | Yang N.-S. | en_US |
dc.contributor.author | Lin Y.-C. | en_US |
dc.contributor.author | Ho S.-T. | en_US |
dc.contributor.author | Li K.-Y. | en_US |
dc.contributor.author | Lin J.-S. | en_US |
dc.contributor.author | Liu J.-R. | en_US |
dc.contributor.author | MING-JU CHEN | en_US |
dc.contributor.author | JE-RUEI LIU | en_US |
dc.creator | Chen Y.-T.;Yang N.-S.;Lin Y.-C.;Ho S.-T.;Li K.-Y.;Lin J.-S.;Liu J.-R.;Chen M.-J. | - |
dc.date.accessioned | 2019-12-19T07:08:14Z | - |
dc.date.available | 2019-12-19T07:08:14Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 20452322 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/435674 | - |
dc.description.abstract | The difficulty of long-term management has produced a high rate of failure for obesity patients. Therefore, improving the efficacy of current obesity treatment is a significant goal. We hypothesized that combining a probiotic Lactobacillus Mali APS1 intervention with dieting could improve the efficacy of obesity and hepatic steatosis treatment compared to dieting alone. Mice were fed a high-fat diet for 6 weeks and then treated with: saline + normal diet and APS1 + normal diet (NDAPS1) for 3 weeks. NDAPS1 accelerated body weight loss and reduced caloric intake and fat accumulation. The fecal microbiome showed that accelerating weight loss by NDAPS1 resulted in restoring intestinal microbiota toward a pre-obese state, with alteration of specific changes in the obesity-associated bacteria. APS1 manipulated the gut microbiome's obesity-associated metabolites, followed by regulation of lipid metabolism, enhancement of energy expenditure and inhibition of appetite. The specific hepatic metabolites induced by the APS1-manipulated gut microbiome also contributed to the amelioration of hepatic steatosis. Our results highlighted a possible microbiome and metabolome that contributed to accelerating weight loss following treatment with a combination of APS1 and dieting and suggested that probiotics could serve as a potential therapy for modulating physiological function and downstream of the microbiota. ? 2018 The Author(s). | - |
dc.relation.ispartof | Scientific Reports | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | hormone; probiotic agent; adipose tissue; animal; body weight loss; caloric intake; diet; disease model; intestine flora; Lactobacillus; liquid chromatography; mass spectrometry; metabolism; metabolomics; mouse; obesity; pathology; procedures; Adipose Tissue; Animals; Chromatography, Liquid; Diet; Disease Models, Animal; Energy Intake; Gastrointestinal Microbiome; Hormones; Lactobacillus; Mass Spectrometry; Metabolomics; Mice; Obesity; Probiotics; Weight Loss | - |
dc.title | A combination of Lactobacillus Mali APS1 and dieting improved the efficacy of obesity treatment via manipulating gut microbiome in mice | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1038/s41598-018-23844-y | - |
dc.identifier.scopus | 2-s2.0-85045739060 | - |
dc.identifier.url | https://www2.scopus.com/inward/record.uri?eid=2-s2.0-85045739060&doi=10.1038%2fs41598-018-23844-y&partnerID=40&md5=89d06c7da66b062a5665acf6b7793406 | - |
dc.relation.journalvolume | 8 | - |
dc.relation.journalissue | 1 | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
crisitem.author.dept | Animal Science and Technology | - |
crisitem.author.dept | Center for Biotechnology | - |
crisitem.author.dept | Biotechnology | - |
crisitem.author.dept | Animal Science and Technology | - |
crisitem.author.orcid | 0000-0003-4403-6112 | - |
crisitem.author.orcid | 0000-0002-2152-7536 | - |
crisitem.author.parentorg | College of Bioresources and Agriculture | - |
crisitem.author.parentorg | Others: University-Level Research Centers | - |
crisitem.author.parentorg | College of Bioresources and Agriculture | - |
crisitem.author.parentorg | College of Bioresources and Agriculture | - |
顯示於: | 動物科學技術學系 |
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