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  1. NTU Scholars
  2. 醫學院
  3. 醫學教育暨生醫倫理學科所
Please use this identifier to cite or link to this item: https://scholars.lib.ntu.edu.tw/handle/123456789/439000
Title: Continuing Decrease in Hepatitis B Virus Infection 30 Years After Initiation of Infant Vaccination Program in Taiwan
Authors: Ni Y.-H.
Chang M.-H.
Jan C.-F.
HONG-YUAN HSU 
Chen H.-L.
Wu J.-F.
Chen D.-S.
Issue Date: 2016
Publisher: W.B. Saunders
Journal Volume: 14
Journal Issue: 9
Start page/Pages: 1324-1330
Source: Clinical Gastroenterology and Hepatology
Abstract: 
Background & Aims Taiwan began a universal hepatitis B virus (HBV) vaccination program for infants in July 1984. The seroprevalence of hepatitis B surface antigen (HBsAg) decreased from 9.8% before the vaccination program to less than 1% by 25 years afterward. We continued to monitor HBV infections in this population. Methods We conducted a series of serologic and epidemiologic surveys in the Taipei metropolitan area every 5 years from 1984 through 2014. From January 1 through December 31 of 2014, we collected serum samples from 4605 apparently healthy individuals (ages: 287 were <3 y, 405 were 3–6 y, 675 were 7–12 y, 686 were 13–18 y, 468 were 18–22 y, and 2084 were 22–50 y). All subjects were tested for HBsAg, its antibody (anti-HBs), and hepatitis B core antibody (anti-HBc). We performed genotype and viral load analyses for patients who tested positive for anti-HBc. Results Of vaccinated participants (age, <30 y; n?= 3299), 0.5% tested positive for HBsAg, 47.4% tested positive for anti-HBs, and 4.5% tested positive for anti-HBc. Of unvaccinated participants (age, 30–50 y, n?= 1306), 6.7% tested positive for HBsAg (P < .0001), 69.4% tested positive for anti-HBs, and 44.1% tested positive for anti-HBc. One occult HBV infection was found in each age group. Among subjects positive for HBsAg younger than age 30, 77% were born to mothers positive for HBsAg. Conclusions Based on a series of serologic and epidemiologic surveys performed in the Taipei metropolitan area, 6.7% of persons born before the universal HBV vaccination program were positive for HBsAg, compared with 0.5% of those born afterward. Most subjects positive for HBsAg younger than age 30 were born to mothers positive for HBsAg. ? 2016 AGA Institute
URI: https://www.scopus.com/inward/record.uri?eid=2-s2.0-84997281825&doi=10.1016%2fj.cgh.2016.04.030&partnerID=40&md5=6e55884fbef01cfa316c78932415ad28
https://scholars.lib.ntu.edu.tw/handle/123456789/439000
ISSN: 1542-3565
DOI: 10.1016/j.cgh.2016.04.030
Appears in Collections:醫學教育暨生醫倫理學科所

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