https://scholars.lib.ntu.edu.tw/handle/123456789/439000
Title: | Continuing Decrease in Hepatitis B Virus Infection 30 Years After Initiation of Infant Vaccination Program in Taiwan | Authors: | Ni Y.-H. Chang M.-H. Jan C.-F. HONG-YUAN HSU Chen H.-L. Wu J.-F. Chen D.-S. |
Issue Date: | 2016 | Publisher: | W.B. Saunders | Journal Volume: | 14 | Journal Issue: | 9 | Start page/Pages: | 1324-1330 | Source: | Clinical Gastroenterology and Hepatology | Abstract: | Background & Aims Taiwan began a universal hepatitis B virus (HBV) vaccination program for infants in July 1984. The seroprevalence of hepatitis B surface antigen (HBsAg) decreased from 9.8% before the vaccination program to less than 1% by 25 years afterward. We continued to monitor HBV infections in this population. Methods We conducted a series of serologic and epidemiologic surveys in the Taipei metropolitan area every 5 years from 1984 through 2014. From January 1 through December 31 of 2014, we collected serum samples from 4605 apparently healthy individuals (ages: 287 were <3 y, 405 were 3–6 y, 675 were 7–12 y, 686 were 13–18 y, 468 were 18–22 y, and 2084 were 22–50 y). All subjects were tested for HBsAg, its antibody (anti-HBs), and hepatitis B core antibody (anti-HBc). We performed genotype and viral load analyses for patients who tested positive for anti-HBc. Results Of vaccinated participants (age, <30 y; n?= 3299), 0.5% tested positive for HBsAg, 47.4% tested positive for anti-HBs, and 4.5% tested positive for anti-HBc. Of unvaccinated participants (age, 30–50 y, n?= 1306), 6.7% tested positive for HBsAg (P < .0001), 69.4% tested positive for anti-HBs, and 44.1% tested positive for anti-HBc. One occult HBV infection was found in each age group. Among subjects positive for HBsAg younger than age 30, 77% were born to mothers positive for HBsAg. Conclusions Based on a series of serologic and epidemiologic surveys performed in the Taipei metropolitan area, 6.7% of persons born before the universal HBV vaccination program were positive for HBsAg, compared with 0.5% of those born afterward. Most subjects positive for HBsAg younger than age 30 were born to mothers positive for HBsAg. ? 2016 AGA Institute |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84997281825&doi=10.1016%2fj.cgh.2016.04.030&partnerID=40&md5=6e55884fbef01cfa316c78932415ad28 https://scholars.lib.ntu.edu.tw/handle/123456789/439000 |
ISSN: | 1542-3565 | DOI: | 10.1016/j.cgh.2016.04.030 |
Appears in Collections: | 醫學教育暨生醫倫理學科所 |
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