https://scholars.lib.ntu.edu.tw/handle/123456789/439024
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | HSIANG-PO HUANG | en_US |
dc.contributor.author | MEI-HWEI CHANG | en_US |
dc.contributor.author | Chen Y.-T. | en_US |
dc.contributor.author | HONG-YUAN HSU | en_US |
dc.contributor.author | Chiang C.-L. | en_US |
dc.contributor.author | Cheng T.-S. | en_US |
dc.contributor.author | YAO-MING WU | en_US |
dc.contributor.author | MU-ZON WU | en_US |
dc.contributor.author | Hsu Y.-C. | en_US |
dc.contributor.author | Shen C.-C. | en_US |
dc.contributor.author | Lee C.-N. | en_US |
dc.contributor.author | YA-HUI CHUANG | en_US |
dc.contributor.author | Hong C.-L. | en_US |
dc.contributor.author | YUNG-MING JENG | en_US |
dc.contributor.author | Chen P.-H. | en_US |
dc.contributor.author | HUEY-LING CHEN | en_US |
dc.contributor.author | MING-SHYUE LEE | en_US |
dc.creator | Lee M.-S.;Chen H.-L.;Chen P.-H.;Jeng Y.-M.;Hong C.-L.;Chuang Y.-H.;Lee C.-N.;Shen C.-C.;Hsu Y.-C.;Wu M.Z.;Wu Y.-M.;Cheng T.-S.;Chiang C.-L.;HONG-YUAN HSU;Chen Y.-T.;Chang M.-H.;Huang H.-P. | - |
dc.date.accessioned | 2019-12-25T04:04:16Z | - |
dc.date.available | 2019-12-25T04:04:16Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 0270-9139 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84155195023&doi=10.1002%2fhep.24657&partnerID=40&md5=86326894ae77458f22dd588127a62d28 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/439024 | - |
dc.description.abstract | Alteration of cell surface proteolysis has been proposed to play a role in liver fibrosis, a grave complication of biliary atresia (BA). In this study we investigated the roles of hepatocyte growth factor activator inhibitor (HAI)-1 and -2 in the progression of BA. The expression levels of HAI-1 and -2 were significantly increased in BA livers compared with those in neonatal hepatitis and correlated with disease progression. In BA livers, HAI-1 and -2 were coexpressed in cells involved in ductular reactions. In other selective cholangiopathies, ductular cells positive for HAI-1 or HAI-2 also increased in number. Inflammatory cytokines, growth factors, and bile acids differentially up-regulated expression of HAI-1 and -2 transcripts in fetal liver cells and this induction could be antagonized by a cyclooxygenase-2 inhibitor. Conditioned media from cell lines stably overexpressing HAI-1 or HAI-2 enhanced the fibrogenic activity of portal fibroblasts and stellate cells, suggesting that both proteins might be involved in liver fibrosis. Because HAI-1 and -2 colocalized in ductular reactions sharing similar features to those observed during normal liver development, we sought to investigate the role of HAI-1 and -2 in cholangiopathies by exploring their functions in fetal liver cells. Knockdown of HAI-1 or HAI-2 promoted bidirectional differentiation of hepatoblast-derived cells. In addition, we showed that the hepatocyte growth factor activator, mitogen-activated protein kinase kinase 1, and phosphatidylinositol 3-kinase signaling pathways were involved in hepatic differentiation enhanced by HAI-2 knockdown. Conclusion: HAI-1 and -2 are overexpressed in the liver in cholangiopathies with ductular reactions and are possibly involved in liver fibrosis and hepatic differentiation; they could be investigated as disease markers and potential therapeutic targets. ? 2011 American Association for the Study of Liver Diseases. | - |
dc.language.iso | English | - |
dc.relation.ispartof | Hepatology | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | Aqp1 protein; carbamoyl phosphate synthase; celecoxib; cell protein; chenodeoxycholic acid; cholic acid; cyclooxygenase 2; cytokeratin 19; deoxycholic acid; hepatocyte growth factor activator; hepatocyte growth factor activator inhibitor 1; hepatocyte growth factor activator inhibitor 2; interleukin 1beta; lithocholic acid; messenger RNA; mitogen activated protein kinase 1; Notch1 receptor; phosphatidylinositol 3 kinase; proteinase; transactivator protein; transforming growth factor beta1; tumor necrosis factor alpha; unclassified drug; animal cell; animal experiment; animal model; article; bile duct atresia; bile duct disease; cell differentiation; cell lineage; controlled study; disease course; extracellular matrix; fetus; gene induction; gene overexpression; gene silencing; hepatic duct; human; human tissue; intracellular signaling; liver cell; liver development; liver fibrosis; mouse; newborn; newborn hepatitis; nonhuman; obstructive jaundice; priority journal; protein expression; protein induction; protein localization; rat; stem cell; upregulation; Animals; Cell Differentiation; Cell Line; Cholestasis; Female; Fibroblasts; Hepatic Stellate Cells; Hepatitis; Hepatocytes; Humans; Infant; Infant, Newborn; Liver Cirrhosis; Male; Membrane Glycoproteins; Membrane Proteins; Mice; Mice, Inbred C57BL; Proteinase Inhibitory Proteins, Secretory; Rats; Signal Transduction; Stem Cells | - |
dc.title | Persistent elevation of hepatocyte growth factor activator inhibitors in cholangiopathies affects liver fibrosis and differentiation | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1002/hep.24657 | - |
dc.identifier.pmid | 21898507 | - |
dc.identifier.scopus | 2-s2.0-84155195023 | - |
dc.relation.pages | 161-172 | - |
dc.relation.journalvolume | 55 | - |
dc.relation.journalissue | 1 | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.languageiso639-1 | English | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
crisitem.author.dept | Medical Genomics and Proteomics | - |
crisitem.author.dept | Pediatrics-NTUH | - |
crisitem.author.dept | Pediatrics-NTUH | - |
crisitem.author.dept | Pediatrics | - |
crisitem.author.dept | Medical Education and Bioethics | - |
crisitem.author.dept | Pediatrics-NTUH | - |
crisitem.author.dept | Surgery | - |
crisitem.author.dept | Surgery-NTUH | - |
crisitem.author.dept | National Taiwan University Cancer Center (NTUCC) | - |
crisitem.author.dept | Surgery-NTUCC | - |
crisitem.author.dept | Forensic Medicine | - |
crisitem.author.dept | Pathology-NTUH | - |
crisitem.author.dept | Clinical Laboratory Sciences and Medical Biotechnology | - |
crisitem.author.dept | Pathology | - |
crisitem.author.dept | Pathology-NTUH | - |
crisitem.author.dept | Medical Education and Bioethics | - |
crisitem.author.dept | Pediatrics-NTUH | - |
crisitem.author.dept | Pediatrics | - |
crisitem.author.dept | Biochemistry and Molecular Biology | - |
crisitem.author.orcid | 0000-0002-3382-305X | - |
crisitem.author.orcid | 0000-0002-3648-9261 | - |
crisitem.author.orcid | 0000-0002-5720-4835 | - |
crisitem.author.orcid | 0000-0002-1720-7863 | - |
crisitem.author.orcid | 0000-0002-7509-1643 | - |
crisitem.author.orcid | 0000-0003-0857-0035 | - |
crisitem.author.orcid | 0000-0002-3878-4491 | - |
crisitem.author.orcid | 0000-0002-4074-5838 | - |
crisitem.author.orcid | 0000-0002-8673-5088 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Cancer Center (NTUCC) | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
顯示於: | 醫學教育暨生醫倫理學科所 |
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