https://scholars.lib.ntu.edu.tw/handle/123456789/439074
標題: | Is extrahepatic biliary atresia related to viral infections? | 作者: | HONG-YUAN HSU | 關鍵字: | Etiology; Extrahepatic biliary atresia; Viral infections | 公開日期: | 2002 | 卷: | 43 | 期: | 2 | 起(迄)頁: | 79-81 | 來源出版物: | Acta Paediatrica Taiwanica | 摘要: | Extrahepatic biliary atresia is characterized by obliteration or absence of the extrahepatic bile ducts in very young infants and ultimately lead to liver cirrhosis and failure. The cause of this disease is currently unknown. There are several hypotheses for the development of extrahepatic biliary atresia. Failure of development or canalization of extrahepatic biliary tree is the unconfirmed old theory. Perinatal insults like viral infections have been suspected as possible etiologies including reovirus type 3, cytomegalovirus and rotavirus, although none of them has been concluded as playing a significant role in the pathogenesis of this disease. By using cultured murine extrahepatic biliary epithelial cell, a virally- induced, immune mediated extrahepatic biliary epithelial cell injury has been demonstrated in our recent work, which may be implicated in the pathogenesis of extrahepatic bilary atresia. Further studies are needed to develop a curative treatment for this serious disorder in the future. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0036264708&partnerID=40&md5=51b0460d6d22ec6e2947b52b2c37f877 https://scholars.lib.ntu.edu.tw/handle/123456789/439074 |
ISSN: | 1608-8115 | SDG/關鍵字: | article; bile duct atresia; cell damage; Cytomegalovirus; disease association; epithelium cell; human; Reovirus; Rotavirus; virus infection; Biliary Atresia; Humans; Virus Diseases |
顯示於: | 醫學教育暨生醫倫理學科所 |
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