https://scholars.lib.ntu.edu.tw/handle/123456789/444357
標題: | A novel long non-coding RNA linc-ZNF469-3 promotes lung metastasis through miR-574-5p-ZEB1 axis in triple negative breast cancer | 作者: | Wang P.-S. Chou C.-H. Lin C.-H. Yao Y.-C. Cheng H.-C. Li H.-Y. Chuang Y.-C. Yang C.-N. Ger L.-P. Chen Y.-C. Lin F.-C. TANG-LONG SHEN Hsiao M. Lu P.-J. |
公開日期: | 2018 | 卷: | 37 | 期: | 34 | 起(迄)頁: | 4662-4678 | 來源出版物: | Oncogene | 摘要: | Triple-negative breast cancer (TNBC) patients usually lead to poor prognosis and survival because of metastasis. The major sites for TNBC metastasis include the lungs, brain, liver, and bone. Long non-coding RNAs (lncRNAs) are non-protein-coding transcripts longer than 200 nucleotides and have been reported as important regulators in BC metastasis. However, the underlying mechanisms for lncRNAs regulating TNBC metastasis are not fully understood. Here we found that linc-ZNF469-3 was highly expressed in lung-metastatic LM2-4175 TNBC cells and overexpression of linc-ZNF469-3 enhanced invasion ability and stemness properties in vitro and lung metastasis in vivo. Furthermore, we found linc-ZNF469-3 physically interacted with miR-574-5p and overexpression of miR-574-5p attenuated ZEB1 expression. Importantly, endogenous high expressions of linc-ZNF469-3 and ZEB1 were correlated with tumor recurrence in TNBC patients with lung metastasis. Taken together, our findings suggested that linc-ZNF469-3 promotes lung metastasis of TNBC through miR-574-5p-ZEB1 signaling axis and may be used as potential prognostic marker for TNBC patients. ? 2018, Macmillan Publishers Limited, part of Springer Nature. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/444357 | ISSN: | 09509232 | DOI: | 10.1038/s41388-018-0293-1 | SDG/關鍵字: | long non coding RNA linc ZNF469 3; long untranslated RNA; microRNA; microRNA 574 5p; unclassified drug; long untranslated RNA; microRNA; MIRN574 microRNA, human; transcription factor; transcription factor ZEB1; tumor marker; ZEB1 protein, human; ZNF469 protein, human; animal experiment; animal model; animal tissue; Article; cancer prognosis; cancer recurrence; cancer stem cell; controlled study; female; gene; gene overexpression; human; human cell; in vitro study; in vivo study; interactions with RNA; lung metastasis; mouse; nonhuman; priority journal; signal transduction; triple negative breast cancer; tumor invasion; ZEB1 gene; animal; cell motion; gene expression regulation; genetics; lung tumor; MCF-7 cell line; metastasis; nonobese diabetic mouse; pathology; SCID mouse; triple negative breast cancer; tumor cell line; tumor recurrence; Animals; Biomarkers, Tumor; Cell Line, Tumor; Cell Movement; Female; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; MCF-7 Cells; Mice; Mice, Inbred NOD; Mice, SCID; MicroRNAs; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Recurrence, Local; RNA, Long Noncoding; Signal Transduction; Transcription Factors; Triple Negative Breast Neoplasms; Zinc Finger E-box-Binding Homeobox 1 |
顯示於: | 植物病理與微生物學系 |
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