Efficient identification of fungal antimicrobial principles by tandem MS and NMR database
Journal
Journal of Food and Drug Analysis
Date Issued
2019
Author(s)
Abstract
C nuclear magnetic resonance (NMR) spectral data compared to the literatures. In addition to nineteen known compounds, a new trichothecene derivative 1, namely trichoverrin D, was isolated and identified through this protocol. The antifungal activities of all the pure isolates were evaluated, and the structure activity relationships were also inferred. This report has demonstrated the combination of HPLC microfractination and MS/MS coupled by NMR spectral dereplication for speeding up the antimicrobial natural products discovery process.
Type
journal article