The association of indoxyl sulfate with fibroblast growth factor-23 in cats with chronic kidney disease
Journal
Journal of Veterinary Internal Medicine
Journal Volume
33
Journal Issue
2
Pages
686-693
Date Issued
2019
Author(s)
Abstract
Background: Indoxyl sulfate (IS) has been reported not only to increase with the severity of impaired renal function, but also possibly to be a factor associated with bone abnormalities linked to fibroblast growth factor-23 (FGF-23) in humans with chronic kidney disease (CKD). It is not yet known whether this correlation between IS and FGF-23 holds true for cats with CKD. Hypothesis: Accumulation of IS is related to FGF-23 secretion in cats with CKD. Animals: Twenty clinically healthy cats and 73 cats with CKD cases were evaluated retrospectively. Methods: The concentrations of IS and FGF-23 in plasma were determined by high-performance liquid chromatography and ELISA, respectively. Progression was defined as an increment of 0.5 mg/dL of serum creatinine concentration within 3 months. Results: Plasma IS and FGF-23 concentrations were significantly increased concurrently with decreasing renal function. Higher concentration of FGF-23 was significantly associated with higher concentration of IS after adjusting for various confounding factors including creatinine and phosphate. Furthermore, the correlation between IS and phosphate was higher than that between FGF-23 and phosphate. When the renal progression group was compared with the non-progression group, both IS and FGF-23 were found to be significantly increased (P <.05). In addition, the area under receiver operator curve of the combination of IS and FGF-23 predicted renal progression at a level >0.9. Conclusions and Clinical Importance: Both FGF-23 and IS are associated with phosphate metabolism and CKD progression. ? 2019 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals, Inc. on behalf of the American College of Veterinary Internal Medicine.
SDGs
Other Subjects
alanine aminotransferase; alkaline phosphatase; aspartate aminotransferase; creatinine; fibroblast growth factor 23; hemoglobin; indican; nitrogen; phosphate; fibroblast growth factor; fibroblast growth factor 23; indican; area under the curve; Article; chronic kidney failure; controlled study; creatinine blood level; drug accumulation; echography; enzyme linked immunosorbent assay; female; hematocrit; high performance liquid chromatography; kidney function; limit of detection; male; nonhuman; phosphate blood level; phosphate metabolism; polyuria; prevalence; proteinuria; receiver operating characteristic; retrospective study; risk factor; urea nitrogen blood level; urinalysis; animal; blood; case control study; cat; cat disease; disease exacerbation; severity of illness index; veterinary medicine; Animals; Case-Control Studies; Cat Diseases; Cats; Chromatography, High Pressure Liquid; Disease Progression; Enzyme-Linked Immunosorbent Assay; Female; Fibroblast Growth Factors; Indican; Male; Renal Insufficiency, Chronic; Retrospective Studies; Severity of Illness Index
Type
journal article