https://scholars.lib.ntu.edu.tw/handle/123456789/444564
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Yeh J.-C. | en_US |
dc.contributor.author | Lo D.-Y. | en_US |
dc.contributor.author | Chang S.-K. | en_US |
dc.contributor.author | Kuo H.-C. | en_US |
dc.contributor.author | SHAO-KUANG CHANG | zz |
dc.creator | Yeh J.-C.;Lo D.-Y.;Chang S.-K.;Kuo H.-C. | - |
dc.date.accessioned | 2020-01-03T06:13:57Z | - |
dc.date.available | 2020-01-03T06:13:57Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 1076-6294 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/444564 | - |
dc.description.abstract | Some members of the Brachyspira genus cause diseases such as swine dysentery (SD) and porcine intestinal (or colonic) spirochetosis. Severe economic losses are caused by decreased feed intake and increased feed conversion ratio, as well as costs associated with treatment and death. A loss of clinical efficacy of some antimicrobial agents authorized for treating SD has been observed in many countries. The aim of this study was to analyze the antimicrobial susceptibility of Brachyspira isolated from Taiwan and to investigate the mechanism of decreased susceptibility to macrolides. A total of 55 Brachyspira isolates obtained from the grower-finisher period were evaluated in this study. These isolates included B. hyodysenteriae (n = 37), B. murdochii (n = 11), B. pilosicoli (n = 5), B. intermedia (n = 1), and B. innocens (n = 1). Antimicrobial susceptibility testing was performed to examine 12 selected antimicrobial agents. The results showed that the 50% and 90% minimum inhibitory concentration (MIC) values of the tested macrolides were all >256 μg/ml. The MIC50 of lincomycin, tiamulin, carbadox, olaquindox, ampicillin, amoxicillin, doxycycline, oxytetracycline, and gentamicin were 32, 1, ?0.125, ?0.125, 0.5, 0.25, 2, 2, and 2 μg/ml. The genetic basis of the decreased susceptibility to tylosin and lincomycin in Brachyspira spp. was investigated and the results showed a possible connection to the mutations at position A2058 and G2032 of the 23S rRNA gene. These findings demonstrated that, in Taiwan, there may be a decrease in susceptibility of Brachyspira spp. to antimicrobials commonly used for the treatment of SD. ? Copyright 2018, Mary Ann Liebert, Inc. | - |
dc.relation.ispartof | Microbial Drug Resistance | - |
dc.subject | antimicrobial susceptibility; Brachyspira; swine dysentery | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | amoxicillin; ampicillin; antibiotic agent; carbadox; doxycycline; gentamicin; lincomycin; macrolide; olaquindox; oxytetracycline; RNA 23S; tiamulin; tylosin; antiinfective agent; antibiotic sensitivity; Article; bacterium isolation; Brachyspira; Brachyspira hyodysenteriae; Brachyspira innocens; Brachyspira intermedia; Brachyspira murdochii; controlled study; drug efficacy; gene mutation; minimum inhibitory concentration; nonhuman; priority journal; Taiwan; animal; antibiotic resistance; Brachyspira; drug effect; isolation and purification; microbial sensitivity test; microbiology; pig; procedures; swine disease; Animals; Anti-Bacterial Agents; Brachyspira; Drug Resistance, Bacterial; Microbial Sensitivity Tests; Swine; Swine Diseases; Taiwan | - |
dc.title | Antimicrobial Susceptibility Patterns of Brachyspira Species Isolated in Taiwan | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1089/mdr.2017.0188 | - |
dc.identifier.scopus | 2-s2.0-85048039450 | - |
dc.identifier.url | https://www2.scopus.com/inward/record.uri?eid=2-s2.0-85048039450&doi=10.1089%2fmdr.2017.0188&partnerID=40&md5=9fbb4d5de87d2fd6ffb77b2cb688ceaf | - |
dc.relation.pages | 685-692 | - |
dc.relation.journalvolume | 24 | - |
dc.relation.journalissue | 5 | - |
item.openairetype | journal article | - |
item.fulltext | no fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
顯示於: | 獸醫學系 |
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