https://scholars.lib.ntu.edu.tw/handle/123456789/444595
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Huang C.-H. | en_US |
dc.contributor.author | Lin Y.-C. | en_US |
dc.contributor.author | TONG-RONG JAN | en_US |
dc.creator | Huang C.-H.;Lin Y.-C.;Jan T.-R. | - |
dc.date.accessioned | 2020-01-03T06:14:06Z | - |
dc.date.available | 2020-01-03T06:14:06Z | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 1756-4646 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/444595 | - |
dc.description.abstract | The effect of Lactobacillus reuteri against food allergy was investigated in ovalbumin (OVA)-sensitized BALB/c mice. Oral administration with L. reuteri restored the deteriorated profile of enteric flora, and attenuated allergic diarrhoea, mast cell activation, and serum IgE production in allergic mice. The production of signature T helper (Th)1 and 2 cytokines, namely IFN-γ and IL-4, by splenocytes was suppressed by L. reuteri. Concordantly, the intestinal expression of IFN-γ, IL-4, T-bet and GATA3 was down-regulated. However, L. reuteri augmented the expression of IL-10, TGF-β and Foxp3, and the number of IL-10-secreting CD11c+CD103+ mesenteric lymph node (MLN) cells. Furthermore, direct exposure to heat-killed L. reuteri attenuated OVA-induced cell proliferation and IL-2 secretion by MLN cells. These results demonstrate that L. reuteri possesses anti-allergic activities via modulating enteric flora and promoting tolerogenic immune responses, and suggest L. reuteri as a functional probiotic against food allergy. ? 2017 Elsevier Ltd | - |
dc.relation.ispartof | Journal of Functional Foods | - |
dc.subject | Food allergy; Lactobacillus reuteri; Regulatory T cell; Tolerogenic dendritic cell | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.title | Lactobacillus reuteri induces intestinal immune tolerance against food allergy in mice | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1016/j.jff.2017.01.034 | - |
dc.identifier.scopus | 2-s2.0-85010377713 | - |
dc.identifier.url | https://www2.scopus.com/inward/record.uri?eid=2-s2.0-85010377713&doi=10.1016%2fj.jff.2017.01.034&partnerID=40&md5=d8244ad5e35a5b8ee0c9f2f4bbe264ba | - |
dc.relation.pages | 44-51 | - |
dc.relation.journalvolume | 31 | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
crisitem.author.dept | Veterinary Medicine | - |
crisitem.author.orcid | 0000-0003-2771-8381 | - |
crisitem.author.parentorg | College of Bioresources and Agriculture | - |
顯示於: | 獸醫學系 |
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