https://scholars.lib.ntu.edu.tw/handle/123456789/446393
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Yi P.-L. | en_US |
dc.contributor.author | Lu C.-Y. | en_US |
dc.contributor.author | Cheng C.-H. | en_US |
dc.contributor.author | Tsai Y.-F. | en_US |
dc.contributor.author | Lin C.-T. | en_US |
dc.contributor.author | FANG-CHIA CHANG | en_US |
dc.contributor.author | CHUNG-TIEN LIN | en_US |
dc.creator | Yi P.-L.;Lu C.-Y.;Cheng C.-H.;Tsai Y.-F.;Lin C.-T.;Chang F.-C. | - |
dc.date.accessioned | 2020-01-07T06:32:21Z | - |
dc.date.available | 2020-01-07T06:32:21Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 1472-6882 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/446393 | - |
dc.description.abstract | Background: The effect of seizure suppression by acupuncture of Feng-Chi (GB20) acupoints has been documented in the ancient Chinese literature, Lingshu Jing (Classic of the Miraculous Pivot), however, there is a lack of scientific evidence to prove it. This current study was designed to elucidate the effect of electroacupuncture (EA) stimulation of bilateral Feng-Chi (GB20) acupoints on the epileptic activity by employing an animal model of focal epilepsy.Methods: Administration of pilocarpine into the left central nucleus of amygdala (CeA) induced the focal epilepsy in rats. Rats received a 30-min 100?Hz EA stimulation of bilateral Feng-Chi acupoints per day, beginning at 30?minutes before the dark period and performing in three consecutive days. The broad-spectrum opioid receptor antagonist (naloxone), μ-receptor antagonist (naloxonazine), δ-receptor antagonist (naltrindole) and κ-receptor antagonist (nor-binaltorphimine) were administered directly into the CeA to elucidate the involvement of CeA opioid receptors in the EA effect.Results: High-frequency (100?Hz) EA stimulation of bilateral Feng-Chi acupoints did not suppress the pilocarpine-induced epileptiform electroencephalograms (EEGs), whereas it further increased the duration of epileptiform EEGs. We also observed that epilepsy occurred while 100?Hz EA stimulation of Feng-Chi acupoints was delivered into na?ve rats. EA-induced augmentation of epileptic activity was blocked by microinjection of naloxone, μ- (naloxonazine), κ- (nor-binaltorphimine) or δ-receptor antagonists (natrindole) into the CeA, suggesting that activation of opioid receptors in the CeA mediates EA-exacerbated epilepsy.Conclusions: The present study suggests that high-frequency (100?Hz) EA stimulation of bilateral Feng-Chi acupoints has no effect to protect against pilocarpine-induced focal epilepsy; in contrast, EA further exacerbated focal epilepsy induced by pilocarpine. Opioid receptors in the CeA mediated EA-induced exacerbation of focal epilepsy. ? 2013 Yi et al.; licensee BioMed Central Ltd. | - |
dc.relation.ispartof | BMC Complementary and Alternative Medicine | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | naloxonazine; naloxone; naltrindole; norbinaltorphimine; opiate receptor; pilocarpine; amygdaloid nucleus; animal experiment; animal model; article; cerebellum; controlled study; disease exacerbation; drug response; electroacupuncture; electrode; electroencephalography; epileptic discharge; focal epilepsy; frontal lobe; male; nonhuman; occipital lobe; parietal lobe; rat; right hemisphere; Acupuncture Points; Amygdala; Animals; Electroacupuncture; Epilepsies, Partial; Humans; Male; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid | - |
dc.title | Activation of amygdala opioid receptors by electroacupuncture of Feng-Chi (GB20) acupoints exacerbates focal epilepsy | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1186/1472-6882-13-290 | - |
dc.identifier.scopus | 2-s2.0-84886391030 | - |
dc.identifier.url | https://www2.scopus.com/inward/record.uri?eid=2-s2.0-84886391030&doi=10.1186%2f1472-6882-13-290&partnerID=40&md5=fd7e6b9cabc48fabcbee2c7bc11026ae | - |
dc.relation.journalvolume | 13 | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
crisitem.author.dept | Veterinary Medicine | - |
crisitem.author.dept | Center for Artificial Intelligence and Advanced Robotics | - |
crisitem.author.dept | Veterinary Clinical Sciences | - |
crisitem.author.orcid | 0000-0003-0271-5416 | - |
crisitem.author.orcid | 0000-0002-3872-152X | - |
crisitem.author.parentorg | College of Bioresources and Agriculture | - |
crisitem.author.parentorg | Others: University-Level Research Centers | - |
crisitem.author.parentorg | College of Bioresources and Agriculture | - |
顯示於: | 臨床動物醫學研究所 |
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