https://scholars.lib.ntu.edu.tw/handle/123456789/449133
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Chang C.-H. | en_US |
dc.contributor.author | Ho C.-T. | en_US |
dc.contributor.author | VIVIAN LIAO | en_US |
dc.creator | Chang C.-H.;Ho C.-T.;Liao V.H.-C. | - |
dc.date.accessioned | 2020-01-14T03:34:13Z | - |
dc.date.available | 2020-01-14T03:34:13Z | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 1613-4125 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/449133 | - |
dc.description.abstract | Scope: Selenium is an essential trace nutrient for human health. This study investigates the organic form of selenium, N-γ-(L-Glutamyl)-L-selenomethionine (Glu-SeMet), for its effects on aging indicators and stress resistance. The role of the selenoprotein TRXR-1 was also evaluated in Caenorhabditis elegans. Methods and results: Glu-SeMet-treated wild-type N2 worms showed increased survival upon oxidative and thermal stress challenges. However, Glu-SeMet treatment did not extend the lifespan of wild-type N2 C. elegans under normal conditions (p = 0.128 for 0.01 μM and p = 0.799 for 10 μM Glu-SeMet). Under stress conditions, Glu-SeMet significantly increased the survival of wild-type N2 C. elegans, but the phenomenon was absent from trxr-1 null mutant worms. Furthermore, Glu-SeMet treatments significantly ameliorated aging indicators, including body bends, pumping rate, defecation duration, and lipofuscin accumulation in wild-type N2 nematodes. Nevertheless, the ameliorative effects by Glu-SeMet were absent in the trxr-1 null mutant worms. Conclusion: The findings indicate that enhanced stress resistance and improved aging indicators by Glu-SeMet in C. elegans are mediated by the selenoprotein TRXR-1. Glu-SeMet has potential for improving health and also provides new insights into selenium's regulatory mechanisms in intact organisms. ? 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim | - |
dc.relation.ispartof | Molecular Nutrition and Food Research | - |
dc.subject | Aging; Caenorhabditis elegans; Selenomethionine; Selenoprotein TRXR-1; Stress resistance | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | Caenorhabditis elegans protein; glutamine; lipofuscin; reactive oxygen metabolite; selenomethionine; selenoprotein; aging; analogs and derivatives; animal; Caenorhabditis elegans; drug effect; genetics; larva; metabolism; mutation; physiological stress; physiology; Aging; Animals; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Glutamine; Larva; Lipofuscin; Mutation; Reactive Oxygen Species; Selenomethionine; Selenoproteins; Stress, Physiological | - |
dc.title | N-γ-(L-Glutamyl)-L-selenomethionine enhances stress resistance and ameliorates aging indicators via the selenoprotein TRXR-1 in Caenorhabditis elegans | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1002/mnfr.201600954 | - |
dc.identifier.scopus | 2-s2.0-85014608171 | - |
dc.identifier.url | https://www2.scopus.com/inward/record.uri?eid=2-s2.0-85014608171&doi=10.1002%2fmnfr.201600954&partnerID=40&md5=98d5545df85ed5271298f0f944c59b8b | - |
dc.relation.journalvolume | 61 | - |
dc.relation.journalissue | 8 | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
crisitem.author.dept | Bioenvironmental Systems Engineering | - |
crisitem.author.orcid | 0000-0002-4676-9953 | - |
crisitem.author.parentorg | College of Bioresources and Agriculture | - |
顯示於: | 生物環境系統工程學系 |
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