https://scholars.lib.ntu.edu.tw/handle/123456789/452187
標題: | Effects of focused ultrasound and microbubbles on the vascular permeability of nanoparticles delivered into mouse tumors | 作者: | Lin C.-Y. Huang Y.-L. Li J.-R. FU-HSIUNG CHANG Win-Li Lin |
公開日期: | 2010 | 卷: | 36 | 期: | 9 | 起(迄)頁: | 1460-1469 | 來源出版物: | Ultrasound in Medicine and Biology | 摘要: | Ultrasound sonication with microbubbles (MBs) was evaluated for enhancement of the release of nanoparticles from vasculature to tumor tissues. In this study, tumor-bearing Balb/c mice were insonicated with focused ultrasound (FUS) in the tumors after the injection of MBs (SonoVue?) and then lipid-coated quantum dot (LQD) nanoparticles (130 ± 25 nm) were injected through the tail vein. We studied the effects of the injected MB dose (0-300 μL/kg), sonication duration (0-300 s) and treatment-procedure sequence on the accumulation of nanoparticles in the tumors 24 h after the treatment and the time response of the accumulation (0.5-24 h). After the treatment, the mice were sacrificed and perfused and then the tumor tissues were harvested for quantifying the amount of nanoparticles using graphite furnace atomic absorption spectrometry (GF-AAS). The results showed that pulsed-FUS sonication with MBs can effectively enhance the vascular permeability for LQD nanoparticle delivery into the sonicated tumors. It indicates that this technique is promising for a better nanodrug delivery for tumor chemotherapy. ? 2010 World Federation for Ultrasound in Medicine & Biology. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-77956053538&doi=10.1016%2fj.ultrasmedbio.2010.06.003&partnerID=40&md5=10c74dea8c620e7c588cf433b502f3cb https://scholars.lib.ntu.edu.tw/handle/123456789/452187 |
ISSN: | 03015629 | DOI: | 10.1016/j.ultrasmedbio.2010.06.003 | SDG/關鍵字: | BALB/c mice; Delivery enhancement; Focused ultrasound; Graphite furnace atomic absorption spectrometry; Microbubbles; Mouse tumors; Quantum Dot; Tail veins; Time response; Tumor tissues; Ultrasound sonications; Vascular permeability; Vasculature; Absorption spectroscopy; Atomic absorption spectrometry; Chemotherapy; Histology; Nanoparticles; Sonication; Ultrasonic applications; Ultrasonics; Tumors; lipid; nanoparticle; quantum dot; sonovue; animal cell; animal experiment; animal model; animal tissue; article; atomic absorption spectrometry; Bagg albino mouse; blood vessel permeability; cancer chemotherapy; cancer tissue; controlled study; dose time effect relation; drug accumulation; drug delivery system; focused ultrasound; male; microbubble; mouse; nonhuman; priority journal; ultrasound; Adenocarcinoma; Animals; Cadmium Compounds; Capillary Permeability; Colorectal Neoplasms; Male; Mice; Mice, Inbred BALB C; Microbubbles; Quantum Dots; Selenium Compounds; Spectrophotometry, Atomic; Time Factors; Tumor Cells, Cultured |
顯示於: | 生物化學暨分子生物學科研究所 |
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