https://scholars.lib.ntu.edu.tw/handle/123456789/452352
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Chang J.-Y. | en_US |
dc.contributor.author | Yu W.-H. | en_US |
dc.contributor.author | Juan H.-F. | en_US |
dc.contributor.author | Huang H.-C. | en_US |
dc.creator | Chang J.-Y.;Yu W.-H.;Juan H.-F.;Huang H.-C. | - |
dc.date.accessioned | 2020-01-22T03:23:05Z | - |
dc.date.available | 2020-01-22T03:23:05Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 0006291X | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/452352 | - |
dc.description.abstract | Alternative polyadenylation (APA) affects the length of the 3′ untranslated region (3′-UTR) and the regulation of microRNAs. Previous studies have shown that cancer cells tend to have shorter 3′-UTRs than normal cells. A plausible explanation for this is that it enables cancer cells to escape the regulation of microRNAs. Here, we extend this concept to an opposing context: changes in 3′-UTR length in the development of the human preimplantation embryo. Unlike cancer cells, during early development 3′-UTRs tended to become longer, and gene expression was negatively correlated with 3′-UTR length. Moreover, our functional enrichment results showed that length changes are part of the development mechanism. We also investigated the analogy of 3′-UTR length variation with respect to lncRNAs and found that, similarly, lncRNA length tended to increase during embryo development. ? 2018 Elsevier Inc. | - |
dc.publisher | Elsevier Inc. | - |
dc.relation.ispartof | Biochemical and Biophysical Research Communications | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | long untranslated RNA; long untranslated RNA; RNA isoform; 3' untranslated region; Article; cancer cell; correlational study; developmental stage; embryo; embryo development; gene expression; genetic variation; genome imprinting; human; polyadenylation; preimplantation embryo; priority journal; trend study; blastocyst; gene expression regulation; gene regulatory network; genetic database; genetics; metabolism; nucleotide sequence; 3' Untranslated Regions; Base Sequence; Blastocyst; Databases, Genetic; Gene Expression Regulation, Developmental; Gene Regulatory Networks; Humans; Polyadenylation; RNA Isoforms; RNA, Long Noncoding | - |
dc.title | Dynamics of alternative polyadenylation in human preimplantation embryos | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1016/j.bbrc.2018.09.027 | - |
dc.identifier.scopus | 2-s2.0-85053021119 | - |
dc.identifier.url | https://www2.scopus.com/inward/record.uri?eid=2-s2.0-85053021119&doi=10.1016%2fj.bbrc.2018.09.027&partnerID=40&md5=25358e3749c7dc395f4ebdfe4d41dcbe | - |
dc.relation.pages | 727-733 | - |
dc.relation.journalvolume | 504 | - |
dc.relation.journalissue | 4 | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
crisitem.author.dept | Molecular and Cellular Biology | - |
crisitem.author.dept | Life Science | - |
crisitem.author.dept | Genome and Systems Biology Degree Program | - |
crisitem.author.dept | Office of Research and Development | - |
crisitem.author.orcid | 0000-0003-4876-3309 | - |
crisitem.author.parentorg | College of Life Science | - |
crisitem.author.parentorg | College of Life Science | - |
crisitem.author.parentorg | College of Life Science | - |
crisitem.author.parentorg | Administrative Unit | - |
顯示於: | 分子與細胞生物學研究所 |
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