https://scholars.lib.ntu.edu.tw/handle/123456789/452806
標題: | Power Doppler vascularity index for predicting the response of neoadjuvant chemotherapy in cervical carcinoma | 作者: | CHI-AN CHEN WEN-FANG CHENG CHIEN-NAN LEE Su Y.-N. CHANG-YAO HSIEH FON-JOU HSIEH |
公開日期: | 2004 | 卷: | 591 | 期: | 597 | 起(迄)頁: | 591-597 | 來源出版物: | Acta Obstetricia et Gynecologica Scandinavica | 摘要: | Background. To evaluate whether the power Doppler vascularity index (PDVI) can predict the response to neoadjuvant chemotherapy (NACT) in cervical carcinoma. Methods. Twenty-five women with bulky early stage cervical carcinoma treated by NACT followed by surgery were enrolled. Their response to NACT was evaluated. Clinical characteristics and pathologic data were recorded. Transvaginal power Doppler was performed before, during and after NACT. PDVI was detected using power Doppler and a quantitative image processing system. Factors that can potentially correlate with the response to NACT were analyzed. Results. Twelve (48%) patients showed a response (responders) to NACT and 13 (52%) were unchanged or had progressive disease (nonresponders) after NACT. Higher PDVI values were noted in tumors with lymphovascular emboli and pelvic lymph node metastasis both before and after NACT. The mean values of the PDVI of the nonresponders before (19.27 ± 6.01 vs. 12.28 ± 7.06, p = 0.014), during (20.2 ± 1.5 vs. 12.9 ± 2.1, p = 0.009) and after NACT (18.1 ± 6.0 vs. 9.3 ± 5.4, p = 0.001) were significantly higher than those of the responders. When the cutoff point for predicting nonresponders to NACT was set at a PDVI value of 15%, the sensitivity was 92.3% and the specificity 66.7%. Conclusions. The power Doppler vascularity index can predict the response to neoadjuvant chemotherapy in cervical cancer, and might be useful for the evaluation of response to chemotherapy in cancer patients in the future. ? Acta Obstet Gynecol Scand 83 2004. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/452806 | DOI: | 10.1111/j.0001-6349.2004.00522.x | SDG/關鍵字: | antineoplastic agent; adjuvant chemotherapy; adult; aged; article; cancer adjuvant therapy; cancer chemotherapy; clinical article; correlation analysis; disease course; Doppler flowmetry; drug response; female; human; human tissue; imaging system; lymph node metastasis; lymph vessel; pelvis lymph node; priority journal; transvaginal echography; treatment outcome; uterine cervix carcinoma; vascularization; Adenocarcinoma; Adult; Aged; Antineoplastic Agents; Carcinoma, Squamous Cell; Female; Humans; Middle Aged; Neoadjuvant Therapy; Neoplasm Staging; Neovascularization, Pathologic; Predictive Value of Tests; Regional Blood Flow; Ultrasonography, Doppler; Uterine Cervical Neoplasms |
顯示於: | 醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。