https://scholars.lib.ntu.edu.tw/handle/123456789/456970
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Liao H.-F. | en_US |
dc.contributor.author | Tai K.-Y. | en_US |
dc.contributor.author | Chen W.S.-C. | en_US |
dc.contributor.author | Cheng L.C. | en_US |
dc.contributor.author | HONG-NERNG HO | en_US |
dc.contributor.author | SHAU-PING LIN | en_US |
dc.creator | Liao H.-F.;Tai K.-Y.;Chen W.S.-C.;Cheng L.C.;Ho H.-N.;Lin S.-P. | - |
dc.date.accessioned | 2020-02-10T09:00:29Z | - |
dc.date.available | 2020-02-10T09:00:29Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 02484900 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/456970 | - |
dc.description.abstract | DNA methyltransferase 3-like (DNMT3L) is one of the key players in de novo DNA methylation of imprinting control elements and retrotransposons, which occurs after genome-wide epigenetic erasure during germ cell development. In this review, we summarise the biochemical properties of DNMT3L and discuss the possible mechanisms behind DNMT3L-mediated imprinting establishment and retrotransposon silencing in germ cells. We also discuss possible connections between DNMT3L and non-coding RNA-mediated epigenetic remodelling, the roles of DNMT3L in germ cell development and the implications in stem cell and cancer research. ? 2012 So?i?t? Francaise des Microscopies and Soci?t? de Biologie Cellulaire de France. | - |
dc.relation.ispartof | Biology of the Cell | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | DNA methyltransferase 3A; DNA methyltransferase 3B; DNA methyltransferase 3L; unclassified drug; untranslated RNA; chromatin; DNA methylation; embryonic stem cell; enzyme activity; epigenetics; gene expression; germ cell; knockout mouse; nonhuman; oocyte; preimplantation embryo; priority journal; protein function; retroposon; review; spermatid; spermatocyte; spermatogonium; Animals; DNA (Cytosine-5-)-Methyltransferase; DNA Methylation; Epigenesis, Genetic; Genome; Genomic Imprinting; Germ Cells; Histone Deacetylases; Histones; Humans; Mice; Neoplasms; Retroelements; Stem Cells | - |
dc.title | Functions of DNA methyltransferase 3-like in germ cells and beyond | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1111/boc.201100109 | - |
dc.identifier.scopus | 2-s2.0-84866934046 | - |
dc.identifier.url | https://www2.scopus.com/inward/record.uri?eid=2-s2.0-84866934046&doi=10.1111%2fboc.201100109&partnerID=40&md5=8c9d8db7bc0c4b9ffd5905e383a4c008 | - |
dc.relation.pages | 571-587 | - |
dc.relation.journalvolume | 104 | - |
dc.relation.journalissue | 10 | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
crisitem.author.dept | Obstetrics & Gynecology | - |
crisitem.author.dept | Obstetrics & Gynecology-NTUH | - |
crisitem.author.dept | Biotechnology | - |
crisitem.author.dept | Genome and Systems Biology Degree Program | - |
crisitem.author.orcid | 0000-0002-7207-0089 | - |
crisitem.author.orcid | 0000-0003-3423-991X | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Bioresources and Agriculture | - |
crisitem.author.parentorg | College of Life Science | - |
顯示於: | 生物科技研究所 |
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