Imprinted microRNA genes transcribed antisense to a reciprocally imprinted retrotransposon-like gene
Journal
Nature Genetics
Journal Volume
34
Journal Issue
3
Pages
261-262
Date Issued
2003
Author(s)
Seitz H.
Youngson N.
Dalbert S.
Paulsen M.
Bachellerie J.-P.
Ferguson-Smith A.C.
Cavaillé J.
Abstract
MicroRNAs (miRNAs) are an abundant class of RNAs that are approximately 21-25 nucleotides (nt) long, interact with mRNAs and trigger either translation repression or RNA cleavage (RNA interference, RNAi) depending on the degree of complementarity with their targets. Here we show that the imprinted mouse distal chromosome 12 locus encodes two miRNA genes expressed from the maternally inherited chromosome and antisense to a retrotransposon-like gene (Rtl1) expressed only from the paternal allele.
SDGs
Type
journal article