https://scholars.lib.ntu.edu.tw/handle/123456789/457160
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | JIN-MING WU | en_US |
dc.contributor.author | TING-CHUN KUO | en_US |
dc.contributor.author | Chen H.-A. | en_US |
dc.contributor.author | CHIEN-HUI WU | en_US |
dc.contributor.author | Lai S.-R. | en_US |
dc.contributor.author | CHING-YAO YANG | en_US |
dc.contributor.author | Hsu S.-Y. | en_US |
dc.contributor.author | Ho T.-W. | en_US |
dc.contributor.author | WEI-CHIH LIAO | en_US |
dc.contributor.author | YU-WEN TIEN | en_US |
dc.creator | Jin-Ming Wu;Kuo T.-C.;Chen H.-A.;Wu C.-H.;Lai S.-R.;Yang C.-Y.;Hsu S.-Y.;Ho T.-W.;Liao W.-C.;Tien Y.-W. | - |
dc.date.accessioned | 2020-02-11T01:41:50Z | - |
dc.date.available | 2020-02-11T01:41:50Z | - |
dc.date.issued | 2019 | - |
dc.identifier.issn | 0007-1323 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85061150052&doi=10.1002%2fbjs.11087&partnerID=40&md5=d11a70233ed09cc931b8e1e4d41d8435 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/457160 | - |
dc.description.abstract | Background: Whether continued oral feeding may have a negative impact on healing of postoperative pancreatic fistula (POPF) is unclear. The aim was to test the hypothesis that oral feeding is non-inferior to enteral feeding in closure of POPF after pancreatoduodenectomy, and to clarify the effects of oral feeding on the duration and grade of POPF. Methods: This multicentre, non-inferiority randomized trial of oral or enteral feeding of patients with POPF after pancreatoduodenectomy recruited patients between August 2013 and September 2016. The primary efficacy outcome was the 30-day fistula closure rate. The prespecified non-inferiority margin was 15 per cent. Other efficacy outcomes included grade of fistula, and hospital stay and costs. Results: A total of 114 patients were included, and received oral (57) or enteral (57) feeding. The two groups were balanced in baseline characteristics and no patient was lost to follow-up. In intention-to-treat analysis, oral feeding was non-inferior to enteral feeding in terms of 30-day fistula closure rate (88 versus 89 per cent respectively; difference –1·8 per cent, lower limit of 95 per cent c.i. –14·4 per cent; P = 0·020 for non-inferiority). Compared with enteral feeding, oral feeding significantly reduced hospital costs and duration of stay. No significant differences were noted in the number of patients whose POPF evolved into grade B/C, or other outcomes. Conclusion: Oral feeding in patients with POPF after pancreatoduodenectomy did not increase the duration or grade of POPF, and was associated with reduced duration of stay and hospital costs. Registration number: NCT01755260 (http://www.clinicaltrials.gov). ? 2019 BJS Society Ltd Published by John Wiley & Sons Ltd | - |
dc.publisher | John Wiley and Sons Ltd | - |
dc.relation.ispartof | British Journal of Surgery | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | amylase; cholecystokinin; abdominal abscess; adult; Article; computer assisted tomography; controlled study; enteric feeding; female; follow up; gastrojejunostomy; hospital cost; hospitalization; human; length of stay; major clinical study; male; middle aged; multicenter study; oral feeding; pancreas fistula; pancreas secretion; pancreaticoduodenectomy; pancreaticojejunostomy; parenteral nutrition; postoperative complication; priority journal; randomized controlled trial; recurrent disease; stomach paresis; clinical trial; comparative study; eating; pancreas fistula; pancreaticoduodenectomy; postoperative care; postoperative complication; procedures; statistics and numerical data; treatment outcome; Eating; Enteral Nutrition; Female; Humans; Length of Stay; Male; Middle Aged; Pancreatic Fistula; Pancreaticoduodenectomy; Postoperative Care; Postoperative Complications; Treatment Outcome | - |
dc.title | Randomized trial of oral versus enteral feeding for patients with postoperative pancreatic fistula after pancreatoduodenectomy | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1002/bjs.11087 | - |
dc.identifier.pmid | 30724356 | - |
dc.identifier.scopus | 2-s2.0-85061150052 | - |
dc.relation.pages | 190-198 | - |
dc.relation.journalvolume | 106 | - |
dc.relation.journalissue | 3 | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
crisitem.author.dept | Surgery-NTUH | - |
crisitem.author.dept | Surgery | - |
crisitem.author.dept | Surgery | - |
crisitem.author.dept | Traumatology-NTUH | - |
crisitem.author.dept | Surgery-NTUH | - |
crisitem.author.dept | Traumatology-NTUH | - |
crisitem.author.dept | Surgery-NTUH | - |
crisitem.author.dept | Surgery-NTUH | - |
crisitem.author.dept | Surgery | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Integrated Diagnostics and Therapeutics-NTUH | - |
crisitem.author.dept | Surgery | - |
crisitem.author.dept | Surgery-NTUH | - |
crisitem.author.orcid | 0000-0002-1821-239X | - |
crisitem.author.orcid | 0000-0003-1960-1423 | - |
crisitem.author.orcid | 0000-0002-6382-1186 | - |
crisitem.author.orcid | 0000-0001-6312-3719 | - |
crisitem.author.orcid | 0000-0001-5362-6953 | - |
crisitem.author.orcid | 0000-0002-9126-2705 | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 醫學系 |
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