https://scholars.lib.ntu.edu.tw/handle/123456789/457799
標題: | Cellular neurothekeoma with atypical features in a child | 作者: | CHENG-MAW HO SHENG-HONG TSENG Tsai C.-C. Chen Y. |
公開日期: | 2005 | 卷: | 17 | 期: | 1 | 起(迄)頁: | 43-45 | 來源出版物: | Tzu Chi Medical Journal | 摘要: | Cellular neurothekeoma (CNT) is an uncommon benign skin neoplasm and a variant of neurothekeoma (NT). Histopathological examination of cellular neurothekeoma often reveals mild cellular atypia and occasional mitoses. CNTs with atypical features (including large size, deep penetration, marked cytologic pleomorphism, high mitotic rate, diffusely infiltrative borders, vascular invasion) are very rare. The rare presence of atypical features may sometimes make CNT difficult to distinguish from soft tissue sarcoma. We describe a case of a 9-year-old girl with a progressively enlarging left thigh tumor (1.5 × 1.3 × 1 cm) over 6 months. After total resection of the tumor, examination revealed histological findings consistent with cellular neurothekeoma but with prominent atypical features, including deep penetration into the subcutaneous adipose tissue, marked cytological pleomorphism, high mitotic rate (5/10HPF), and diffusely infiltrative border. Immunohistochemically, these cells were positive for α-smooth muscle actin, but negative for cytokeratin and S-100. Her clinical course was uneventful without recurrence after one and a half years of follow-up. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-14244255648&partnerID=40&md5=ed7a575a783a065f172b137ca8f6b2c9 https://scholars.lib.ntu.edu.tw/handle/123456789/457799 |
ISSN: | 1016-3190 | SDG/關鍵字: | alpha smooth muscle actin; cytokeratin; protein S 100; adipose tissue; article; benign tumor; case report; cell type; clinical feature; female; follow up; histopathology; human; human tissue; immunohistochemistry; mitosis; mitosis rate; nerve sheath tumor; recurrent disease; school child; soft tissue sarcoma; thigh |
顯示於: | 醫學系 |
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