https://scholars.lib.ntu.edu.tw/handle/123456789/458229
標題: | Tumor-associated carbonic anhydrase XII is linked to the growth of primary oral squamous cell carcinoma and its poor prognosis | 作者: | Chien M.-H Ying T.-H Hsieh Y.-H Lin C.-H Shih C.-H LING-HUNG WEI Yang S.-F. |
關鍵字: | Carbonic anhydrase XII; Oral squamous cell carcinoma; Prognosis; Tissue microarray | 公開日期: | 2012 | 卷: | 48 | 期: | 5 | 起(迄)頁: | 417-423 | 來源出版物: | Oral Oncology | 摘要: | The pattern of protein expression in tumors is under the influence of nutrient stress, hypoxia, and low pH, which determines the survival of neoplastic cells and the development of tumors. Carbonic anhydrase (CA) XII is a transmembrane enzyme that catalyzes the reversible hydration of cell-generated carbon dioxide into protons and bicarbonate. Hypoxic conditions activate its transcription and translation, and enhanced expression is often present in several types of tumors. However, CA XII expression in oral squamous cell carcinoma (OSCC) and its correlation with patients' prognosis have not been investigated so far. In this study, we detected the expression of CA XII in 264 patients with OSCC using tissue microarrays (TMAs), and evaluated its correlation with clinicopathologic factors and disease prognosis. CA XII expression was present in 185/264 (70%) cases and was associated with more-advanced clinical stages (p = 0.003), a larger tumor size (p < 0.001), and postoperative recurrence (p = 0.047), but was not associated with positive lymph node metastasis or distal metastasis. Importantly, CA XII expression was correlated with a poorer patient prognosis in a univariate (p = 0.034, log-rank test) survival analysis. According to our results, the expression of CA XII in OSCC samples can predict the progression of OSCC and survival of OSCC patients. ? 2011 Elsevier Ltd. All rights reserved. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/458229 | ISSN: | 1368-8375 | DOI: | 10.1016/j.oraloncology.2011.11.015 | SDG/關鍵字: | carbonate dehydratase XII; adult; advanced cancer; aged; article; cancer growth; cancer prognosis; cancer recurrence; cancer staging; cancer survival; distant metastasis; female; histopathology; human; lymph node metastasis; major clinical study; male; mouth carcinoma; oral squamous cell carcinoma; predictive validity; priority journal; protein expression; squamous cell carcinoma; tissue microarray; tumor volume; Adult; Aged; Aged, 80 and over; Carbonic Anhydrases; Carcinoma, Squamous Cell; Disease Progression; Female; Humans; Male; Middle Aged; Mouth Neoplasms; Neoplasm Metastasis; Prognosis; Survival Analysis; Survival Rate; Tumor Markers, Biological |
顯示於: | 醫學系 |
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