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  1. NTU Scholars
  2. 醫學院
  3. 醫學系
Please use this identifier to cite or link to this item: https://scholars.lib.ntu.edu.tw/handle/123456789/458264
DC FieldValueLanguage
dc.contributor.authorWEN-FANG CHENGen_US
dc.contributor.authorLING-HUNG WEIen_US
dc.contributor.authorSu Y.-Nen_US
dc.contributor.authorCheng S.-Pen_US
dc.contributor.authorChu J.-Sen_US
dc.contributor.authorCHIEN-NAN LEEen_US
dc.creatorLee C.-N.;Chu J.-S;Cheng S.-P;Su Y.-N;LING-HUNG WEI;Cheng W.-F-
dc.date.accessioned2020-02-12T05:48:36Z-
dc.date.available2020-02-12T05:48:36Z-
dc.date.issued1999-
dc.identifier.issn1470-0328-
dc.identifier.urihttps://scholars.lib.ntu.edu.tw/handle/123456789/458264-
dc.description.abstractObjective To investigate the pathological significance of intra-tumoural blood flow signals detected by colour Doppler ultrasound and their association with angiogenesis in cervical carcinoma. Design A prospective cross-sectional study. Setting University hospital. Population One hundred and four women with Stage IB-IIA cervical carcinoma. Methods All women underwent radical hysterectomy and pelvic lymph node dissection. Transvaginal colour Doppler ultrasound was performed before surgery to search for arterial blood flow signals within the tumours. Tumours with a measurable intra-tumoural resistance index were defined as tumour with detectable blood flow and the others as tumour with undetectable blood flow. The microvessel density of the excised tumour was assessed immunohistochemically. The women’s clinical and pathologic data were recorded. Results There were 60 tumours (58%) exhibiting detectable intra-tumoural blood flow signals. Tumours with detectable blood flow were larger, had deeper cervical stromal invasion, a higher incidence of parametrial invasion and pelvic lymph node metastases, and a higher microvessel density, when compared with those without detectable blood flow. Cervical cancers with deep cervical stromal invasion, parametrial invasion, and pelvic lymph node metastasis had higher microvessel density than those with superficial stromal invasion, no parametrial invasion, or no lymph node metastasis. Microvessel density correlated well with lymph node metastases and parametrial invasion by multiple regression analysis, while intra-tumoural blood signals only showed correlation with parametrial invasion. In the prediction of pelvic lymph node metastases and parametrial invasion, colour flow Doppler had a sensitivity of 0.80 and specificity of 0.48 in predicting lymph node metastases, and sensitivity of 0-91 and specificity of 0.57 in predicting parametrial invasion. Conclusions The characteristics of blood flow signals in cervical carcinoma detected by colour Doppler ultrasound are associated with tumour angiogenesis and could reflect the likelihood of parametrial invasion and lymph node metastases in cervical carcinoma. The intra-tumoural blood flow signals might be used as a screening test in predicting parametrial invasion and pelvic lymph node metastases. These findings may be helpful in planning treatment for women with Stage I and II cervical carcinoma. ? 1999 Blackwell Publishing Ltd.-
dc.relation.ispartofBJOG: An International Journal of Obstetrics and Gynaecology-
dc.subject.otheradult; angiogenesis; artery blood flow; article; cancer surgery; color ultrasound flowmetry; diagnostic accuracy; female; human; immunohistochemistry; lymph node dissection; lymph node metastasis; major clinical study; pathology; pelvis lymph node; priority journal; prospective study; radical hysterectomy; transvaginal echography; treatment planning; tumor blood flow; uterine cervix carcinoma; Adenocarcinoma; Blood Flow Velocity; Carcinoma, Squamous Cell; Cross-Sectional Studies; Female; Humans; Middle Aged; Neoplasm Staging; Neovascularization, Pathologic; Prospective Studies; Regression Analysis; Ultrasonography, Doppler, Color; Uterine Cervical Neoplasms-
dc.subject.other[SDGs]SDG3-
dc.titleThe possible use of colour flow Doppler in planning treatment in early invasive carcinoma of the cervixen_US
dc.typejournal article-
dc.identifier.doi10.1111/j.1471-0528.1999.tb08138.x-
dc.identifier.pmid10549957-
dc.identifier.scopus2-s2.0-0032718754-
dc.relation.pages1137-1142-
dc.relation.journalvolume106-
dc.relation.journalissue11-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_6501-
item.openairetypejournal article-
item.fulltextno fulltext-
item.cerifentitytypePublications-
crisitem.author.deptObstetrics & Gynecology-
crisitem.author.deptObstetrics & Gynecology-NTUH-
crisitem.author.deptObstetrics & Gynecology-
crisitem.author.deptObstetrics & Gynecology-NTUH-
crisitem.author.deptOncology-NTUH-
crisitem.author.deptObstetrics & Gynecology-
crisitem.author.deptMedical Genetics-NTUH-
crisitem.author.deptObstetrics & Gynecology-NTUH-
crisitem.author.orcid0000-0002-3282-6304-
crisitem.author.orcid0000-0001-8789-0859-
crisitem.author.orcid0000-0002-1725-0407-
crisitem.author.parentorgCollege of Medicine-
crisitem.author.parentorgNational Taiwan University Hospital-
crisitem.author.parentorgCollege of Medicine-
crisitem.author.parentorgNational Taiwan University Hospital-
crisitem.author.parentorgNational Taiwan University Hospital-
crisitem.author.parentorgCollege of Medicine-
crisitem.author.parentorgNational Taiwan University Hospital-
crisitem.author.parentorgNational Taiwan University Hospital-
Appears in Collections:醫學系
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臺大位居世界頂尖大學之列,為永久珍藏及向國際展現本校豐碩的研究成果及學術能量,圖書館整合機構典藏(NTUR)與學術庫(AH)不同功能平台,成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。

To permanently archive and promote researcher profiles and scholarly works, Library integrates the services of “NTU Repository” with “Academic Hub” to form NTU Scholars.

總館學科館員 (Main Library)
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開放取用是從使用者角度提升資訊取用性的社會運動,應用在學術研究上是透過將研究著作公開供使用者自由取閱,以促進學術傳播及因應期刊訂購費用逐年攀升。同時可加速研究發展、提升研究影響力,NTU Scholars即為本校的開放取用典藏(OA Archive)平台。(點選深入了解OA)

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