https://scholars.lib.ntu.edu.tw/handle/123456789/458280
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Chou C.-H | en_US |
dc.contributor.author | SHEE-UAN CHEN | en_US |
dc.contributor.author | CHIA-TUNG SHUN | en_US |
dc.contributor.author | PO-NIEN TSAO | en_US |
dc.contributor.author | YU-SHIH YANG | en_US |
dc.contributor.author | JEHN-HSIAHN YANG | en_US |
dc.creator | Chou C.-H;Chen S.-U;Shun C.-T;Tsao P.-N;Yang Y.-S;Jehn-Hsiahn Yang | - |
dc.date.accessioned | 2020-02-13T00:54:53Z | - |
dc.date.available | 2020-02-13T00:54:53Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/458280 | - |
dc.description.abstract | Endometrial inflammation has contradictory effects. The one occurring at peri-implantation period is favourable for embryo implantation, whereas the other occurring after the stimulation by copper intrauterine device (Cu-IUD) prevents from embryo implantation. In this study, 8 week female ICR mice were used to investigate the endometrial inflammation, in which they were at proestrus stage (Group 1), at peri-implantation period (Group 2), and had a copper wire implanted into right uterine horn (Group 3). Cytokine array revealed that two cytokines were highly expressed in Group 2 and Group 3 as compared with Group 1, and seven cytokines, including tumour necrosis factor α (TNF-α), had selectively strong expression in Group 3. Immunohistochemistry demonstrated prominent TNF-α staining on the endometrium after Cu-IUD stimulation, and in vitro culture of human endometrial glandular cells with Cu induced TNF-α secretion. The increased TNF-α concentration enhanced in vitro THP-1 cells chemotaxis, and reduced embryo implantation rates. These results suggest that inflammatory cytokine profiles of endometrium are different between those at peri-implantation period and after Cu-IUD stimulation, and TNF-α is the one with selectively strong expression in the latter. It might account for the contradictory biological effects of endometrial inflammation. | - |
dc.relation.ispartof | Scientific Reports | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | copper; cytokine; tumor necrosis factor; animal; cell culture; chemistry; chemotaxis; copper intrauterine device; cytology; drug effects; endometrium; female; human; immunohistochemistry; inflammation; Institute for Cancer Research mouse; metabolism; mouse; nidation; protein microarray; secretion (process); Animals; Cells, Cultured; Chemotaxis; Copper; Cytokines; Embryo Implantation; Endometrium; Female; Humans; Immunohistochemistry; Inflammation; Intrauterine Devices, Copper; Mice; Mice, Inbred ICR; Protein Array Analysis; Tumor Necrosis Factor-alpha | - |
dc.title | Divergent endometrial inflammatory cytokine expression at peri-implantation period and after the stimulation by copper intrauterine device | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1038/srep15157 | - |
dc.identifier.pmid | 26469146 | - |
dc.identifier.scopus | 2-s2.0-84944706027 | - |
dc.relation.pages | 15157 | - |
dc.relation.journalvolume | 5 | - |
item.openairetype | journal article | - |
item.fulltext | no fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | Obstetrics & Gynecology | - |
crisitem.author.dept | Obstetrics & Gynecology-NTUH | - |
crisitem.author.dept | Forensic Medicine | - |
crisitem.author.dept | Pediatrics | - |
crisitem.author.dept | Pediatrics-NTUH | - |
crisitem.author.dept | Obstetrics & Gynecology | - |
crisitem.author.dept | Obstetrics & Gynecology-NTUH | - |
crisitem.author.dept | Obstetrics & Gynecology | - |
crisitem.author.dept | Obstetrics & Gynecology-NTUH | - |
crisitem.author.orcid | 0000-0001-7592-3238 | - |
crisitem.author.orcid | 0000-0002-0468-4468 | - |
crisitem.author.orcid | 0000-0002-6114-1769 | - |
crisitem.author.orcid | 0000-0002-8633-0873 | - |
crisitem.author.orcid | 0000-0001-8648-0882 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
Appears in Collections: | 醫學系 |
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