https://scholars.lib.ntu.edu.tw/handle/123456789/458764
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Cheng, Yung-Ting | en_US |
dc.contributor.author | CHAO-YUAN HUANG | en_US |
dc.contributor.author | CHUNG-HSIN CHEN | en_US |
dc.contributor.author | Chiu, Shih-Ting | en_US |
dc.contributor.author | JIAN-HUA HONG | en_US |
dc.contributor.author | YEONG-SHIAU PU | en_US |
dc.contributor.author | SHIH-PING LIU | en_US |
dc.contributor.author | YU-CHUAN LU | en_US |
dc.contributor.author | YI-KAI CHANG | en_US |
dc.contributor.author | HONG-CHIANG CHANG | en_US |
dc.contributor.author | KUO-HOW HUANG | en_US |
dc.contributor.author | YUAN-JU LEE | en_US |
dc.contributor.author | PO-MING CHOW | en_US |
dc.contributor.author | I-NI CHIANG | en_US |
dc.contributor.author | Hung, Shih-Chun | en_US |
dc.contributor.author | Chiang, Chih-Hung | en_US |
dc.creator | Chiang C.-H.;Hung S.-C.;Chiang I.-N.;Chow P.-M.;Lee Y.-J.;Huang K.-H.;Chang H.-C.;Chang Y.-K.;YU-CHUAN LU;Liu S.-P.;Pu Y.-S.;Hong J.-H.;Chiu S.-T.;Chen C.-H.;Huang C.-Y.;Cheng Y.-T. | - |
dc.date.accessioned | 2020-02-14T04:16:49Z | - |
dc.date.available | 2020-02-14T04:16:49Z | - |
dc.date.issued | 2020 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/458764 | - |
dc.description.abstract | To evaluate the predictive accuracy of the %p2PSA and prostate health index (PHI) in predicting aggressive pathological outcomes in patients with prostate cancer (PCa) undergoing radical prostatectomy (RP), we enrolled 91 patients with organ-confined PCa who were treated with robot-assisted RP. p2PSA levels and the PHI were investigated for their ability to predict pathological results. The %p2PSA and PHI were both significantly higher in patients with ?pT3 disease, high-risk disease, positive surgical margin, or seminal vesical invasion (SVI). In univariable analysis, p2PSA derivatives were significant predictors of the presence of ?pT3 disease, high-risk disease, positive surgical margin, and SVI. To predict adverse pathological outcomes at a sensitivity of 90%, p2PSA derivatives had higher specificity than standard PSA derivatives. In multivariable analysis, additional increases in the area under the receiver operating characteristic curve (AUC) were observed with the %p2PSA and PHI for ?pT3 disease, high-risk disease, and positive surgical margin (8.2% and 2.7%, 6.2% and 4.1%, and 8.6% and 5.4%, respectively). A PHI ?61.26 enhanced the predictive accuracy of the model for SVI by increasing the AUC from 0.624 to 0.819 (p = 0.009). The preoperative %p2PSA and PHI accurately predict adverse pathological results and are useful for decision-making. ? 2020, The Author(s). | - |
dc.relation.ispartof | Scientific Reports | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | prostate specific antigen; tumor marker; aged; human; male; metabolism; middle aged; preoperative period; procedures; prognosis; prospective study; prostate tumor; prostatectomy; receiver operating characteristic; treatment outcome; Aged; Biomarkers, Tumor; Humans; Male; Middle Aged; Preoperative Period; Prognosis; Prospective Studies; Prostate-Specific Antigen; Prostatectomy; Prostatic Neoplasms; ROC Curve; Treatment Outcome | - |
dc.title | Preoperative %p2PSA and Prostate Health Index Predict Pathological Outcomes in Patients with Prostate Cancer Undergoing Radical Prostatectomy | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1038/s41598-020-57618-2 | - |
dc.identifier.scopus | 2-s2.0-85078212529 | - |
dc.relation.journalvolume | 10 | - |
dc.relation.journalissue | 1 | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
crisitem.author.dept | Urology | - |
crisitem.author.dept | Urology-NTUH | - |
crisitem.author.dept | Urology | - |
crisitem.author.dept | Urology-NTUH | - |
crisitem.author.dept | Urology-NTUH | - |
crisitem.author.dept | Surgical Oncology-NTUCC | - |
crisitem.author.dept | Urology | - |
crisitem.author.dept | Urology-NTUH | - |
crisitem.author.dept | Surgical Oncology-NTUCC | - |
crisitem.author.dept | Urology-NTUHBP | - |
crisitem.author.dept | Urology-NTUH | - |
crisitem.author.dept | Urology | - |
crisitem.author.dept | Urology | - |
crisitem.author.dept | Surgical Oncology-NTUCC | - |
crisitem.author.dept | Urology-NTUH | - |
crisitem.author.dept | Urology-NTUH | - |
crisitem.author.dept | Urology-NTUHBP | - |
crisitem.author.dept | Surgical Oncology-NTUCC | - |
crisitem.author.dept | Urology-NTUH | - |
crisitem.author.dept | Urology | - |
crisitem.author.dept | Urology-NTUH | - |
crisitem.author.dept | Surgical Oncology-NTUCC | - |
crisitem.author.dept | Urology-NTUH | - |
crisitem.author.dept | Urology-NTUHBH | - |
crisitem.author.dept | Urology | - |
crisitem.author.dept | Urology-NTUH | - |
crisitem.author.dept | Urology-NTUH | - |
crisitem.author.dept | Urology | - |
crisitem.author.orcid | 0000-0002-9322-6062 | - |
crisitem.author.orcid | 0000-0002-4921-5315 | - |
crisitem.author.orcid | 0000-0001-6054-0728 | - |
crisitem.author.orcid | 0000-0002-2859-3966 | - |
crisitem.author.orcid | 0000-0002-8015-0695 | - |
crisitem.author.orcid | 0000-0001-8264-179X | - |
crisitem.author.orcid | 0000-0001-5411-6680 | - |
crisitem.author.orcid | 0000-0002-0989-0578 | - |
crisitem.author.orcid | 0000-0002-3183-1830 | - |
crisitem.author.orcid | 0000-0003-1013-5227 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Cancer Center (NTUCC) | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Cancer Center (NTUCC) | - |
crisitem.author.parentorg | NTU BioMedical Park Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Cancer Center (NTUCC) | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | NTU BioMedical Park Hospital | - |
crisitem.author.parentorg | National Taiwan University Cancer Center (NTUCC) | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Cancer Center (NTUCC) | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital Bei-Hu Branch | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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