https://scholars.lib.ntu.edu.tw/handle/123456789/459965
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | MING-YIH WU | en_US |
dc.contributor.author | KUANG-HAN CHAO | en_US |
dc.contributor.author | SHEE-UAN CHEN | en_US |
dc.contributor.author | HSIN-FU CHEN | en_US |
dc.contributor.author | YU-SHIH YANG | en_US |
dc.contributor.author | Huang S.-C | en_US |
dc.contributor.author | HONG-NERNG HO | en_US |
dc.creator | Ming-Yih Wu;Chao K.-H;Chen S.-U;Chen H.-F.U;Yang Y.U.-S;Huang S.U.-C;Ho H.-N. | - |
dc.date.accessioned | 2020-02-17T07:02:14Z | - |
dc.date.available | 2020-02-17T07:02:14Z | - |
dc.date.issued | 1996 | - |
dc.identifier.issn | 8755-8920 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/459965 | - |
dc.description.abstract | Problem: Our previous study reported that peritoneal natural killer (NK) cytotoxicity and CD3+CD25+ lymphocyte subpopulation were suppressed in women with advanced endometriosis. Whether these phenomena are general for all stages of endometriosis and whether these alterations could be restored by long-term use of gonadotropin releasing hormone agonist (GnRHa) are further tested in this study. Method: Lymphocyte subpopulations (B cells, NK cells, T cells, and T-cell activation markers such as CD69, HLA-DR, and CD25) and NK cell cytotoxicity of peripheral blood and peritoneal fluid by dual-color flow cytometry and 51Cr release assay in 30 cases of endometriosis were compared with those in 26 controls. We also compared these changes before and after 6-month treatment with GnRHa for advanced endometriosis. Results: Compared with the controls, only those women with advanced endometriosis showed lower NK cytotoxicity in peritoneal fluid mononuclear cells (PFMC). The CD3+CD69+ lymphocyte subpopulation decreased in peripheral blood mononuclear cells (PBMC) of advanced endometriosis, while the CD3+CD25+ lymphocyte subpopulation decreased in both PBMC and PFMC of mild and advanced endometriosis. After GnRHa treatment, the CD3+CD69+ lymphocyte subpopulation increased in both PBMC and PFMC and the CD3+CD25+ lymphocyte subpopulation increased in PFMC, but not in PBMC. Conclusion: Impaired local immunological function in the PF of endometriosis was confirmed by this study and the impairments could be restored after long-term GnRHa therapy. | - |
dc.relation.ispartof | American Journal of Reproductive Immunology | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | CD3 antigen; CD69 antigen; chromium 51; gonadorelin agonist; HLA DR antigen; interleukin 2 receptor; leuprorelin; article; B lymphocyte; cell mediated cytotoxicity; cellular immunity; cellular immunodeficiency; clinical article; controlled study; disease severity; endometriosis; female; flow cytometry; human; human cell; lymphocyte subpopulation; mononuclear cell; natural killer cell; peritoneal fluid; priority journal; subcutaneous drug administration; T lymphocyte activation | - |
dc.title | The suppression of peritoneal cellular immunity in women with endometriosis could be restored after gonadotropin releasing hormone agonist treatment | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1111/j.1600-0897.1996.tb00050.x | - |
dc.identifier.pmid | 8792933 | - |
dc.identifier.scopus | 2-s2.0-0029897589 | - |
dc.relation.pages | 510-516 | - |
dc.relation.journalvolume | 35 | - |
dc.relation.journalissue | 6 | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
crisitem.author.dept | Obstetrics & Gynecology-NTUH | - |
crisitem.author.dept | Obstetrics & Gynecology-NTUH | - |
crisitem.author.dept | Obstetrics & Gynecology | - |
crisitem.author.dept | Obstetrics & Gynecology-NTUH | - |
crisitem.author.dept | Obstetrics & Gynecology-NTUH | - |
crisitem.author.dept | Medical Genomics and Proteomics | - |
crisitem.author.dept | Obstetrics & Gynecology | - |
crisitem.author.dept | Clinical Medicine | - |
crisitem.author.dept | Obstetrics & Gynecology | - |
crisitem.author.dept | Obstetrics & Gynecology-NTUH | - |
crisitem.author.dept | Obstetrics & Gynecology | - |
crisitem.author.dept | Obstetrics & Gynecology-NTUH | - |
crisitem.author.orcid | 0000-0001-6587-7055 | - |
crisitem.author.orcid | 0000-0001-8124-1516 | - |
crisitem.author.orcid | 0000-0001-7592-3238 | - |
crisitem.author.orcid | 0000-0002-7748-4440 | - |
crisitem.author.orcid | 0000-0002-8633-0873 | - |
crisitem.author.orcid | 0000-0002-7207-0089 | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 醫學系 |
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