https://scholars.lib.ntu.edu.tw/handle/123456789/460111
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | HONG-NERNG HO | en_US |
dc.contributor.author | KUANG-HAN CHAO | en_US |
dc.contributor.author | HSIN-FU CHEN | en_US |
dc.contributor.author | SHEE-UAN CHEN | en_US |
dc.contributor.author | MING-YIH WU | en_US |
dc.contributor.author | YU-SHIH YANG | en_US |
dc.creator | Hong-Nerng Ho;Chao K.-H;Chen H.-F;Chen S.-U;Wu M.-Y;Yang Y.-S. | - |
dc.date.accessioned | 2020-02-17T07:43:55Z | - |
dc.date.available | 2020-02-17T07:43:55Z | - |
dc.date.issued | 2001 | - |
dc.identifier.issn | 0015-0282 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/460111 | - |
dc.description.abstract | Objective: To examine whether maternal immune responses during normal pregnancy are Th2 biased and whether there are specific changes when anembryonic pregnancy occurs. Design: Prospective study. Setting: Department of Obstetrics and Gynecology at a university hospital. Patient(s): We studied 32 pregnant women receiving elective abortions of normal pregnancies and 35 women with anembryonic pregnancies between 6 weeks and 10 weeks of gestational age. Intervention(s): Using the multilabeling capability of three-color flow cytometry, it is possible to measure intracellular cytokines and cell surface markers simultaneously to determine which cells are the cytokine-producing cells. Main Outcome Measure(s): We examined the extent and proportion of mononuclear cells expressing specific T-cell surface markers and cytokines, interferon γ, and interleukin 4 in the peripheral blood and deciduae. Secreted cytokines in the supernatants after 24-hour culture were also compared. Result(s): During the unstimulated status, the proportion of IL-4-secreting cells significantly exceeded that of IFN-γ-secreting cells in the peripheral blood and decidua in normal pregnancies and was significantly decreased when anembryonic pregnancies occurred. Consequently, the Th1/Th2 ratios were increased during anembryonic pregnancies. However, after 24-hour culture, only another Th2-type cytokine, IL-10, was markedly increased and exceeded IFN-γ secretion in cultures from both the peripheral blood and decidua in normal pregnancies. Conclusion(s): The decidual T lymphocytes are Th2 predominant. When anembryonic pregnancy occurs, this Th2 predominance disappears. ? 2001 by American Society for Reproductive Medicine. | - |
dc.relation.ispartof | Fertility and Sterility | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | cell surface marker; cytokine; gamma interferon; interleukin 10; interleukin 4; article; cell culture; cell population; cell secretion; cell specificity; cell surface; cellular distribution; clinical article; controlled study; cytokine production; decidua; embryo; female; flow cytometry; gestational age; human; human cell; immune response; mononuclear cell; pregnancy; priority journal; T lymphocyte; Th1 cell; Th2 cell; Cytokines; Decidua; Female; Fetal Death; Humans; Kinetics; Pregnancy; Prospective Studies; Reference Values; Th1 Cells; Th2 Cells | - |
dc.title | Distribution of Th1 and Th2 cell populations in human peripheral and decidual T cells from normal and anembryonic pregnancies | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1016/S0015-0282(01)01999-9 | - |
dc.identifier.pmid | 11591416 | - |
dc.identifier.scopus | 2-s2.0-0034809013 | - |
dc.relation.pages | 797-803 | - |
dc.relation.journalvolume | 76 | - |
dc.relation.journalissue | 4 | - |
item.fulltext | no fulltext | - |
item.cerifentitytype | Publications | - |
item.openairetype | journal article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.grantfulltext | none | - |
crisitem.author.dept | Obstetrics & Gynecology | - |
crisitem.author.dept | Obstetrics & Gynecology-NTUH | - |
crisitem.author.dept | Obstetrics & Gynecology-NTUH | - |
crisitem.author.dept | Obstetrics & Gynecology-NTUH | - |
crisitem.author.dept | Medical Genomics and Proteomics | - |
crisitem.author.dept | Obstetrics & Gynecology | - |
crisitem.author.dept | Clinical Medicine | - |
crisitem.author.dept | Obstetrics & Gynecology | - |
crisitem.author.dept | Obstetrics & Gynecology-NTUH | - |
crisitem.author.dept | Obstetrics & Gynecology-NTUH | - |
crisitem.author.dept | Obstetrics & Gynecology | - |
crisitem.author.dept | Obstetrics & Gynecology-NTUH | - |
crisitem.author.orcid | 0000-0002-7207-0089 | - |
crisitem.author.orcid | 0000-0001-8124-1516 | - |
crisitem.author.orcid | 0000-0002-7748-4440 | - |
crisitem.author.orcid | 0000-0001-7592-3238 | - |
crisitem.author.orcid | 0000-0001-6587-7055 | - |
crisitem.author.orcid | 0000-0002-8633-0873 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 醫學系 |
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