https://scholars.lib.ntu.edu.tw/handle/123456789/460198
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Giorgi J.V | en_US |
dc.contributor.author | HONG-NERNG HO | en_US |
dc.contributor.author | Hirji K | en_US |
dc.contributor.author | Chou C.-C | en_US |
dc.contributor.author | Hultin L.E | en_US |
dc.contributor.author | Rourke S O' | en_US |
dc.contributor.author | Park L | en_US |
dc.contributor.author | Margolick J.B | en_US |
dc.contributor.author | Ferbas J | en_US |
dc.contributor.author | Phair J.P | en_US |
dc.contributor.author | Saah A.J | en_US |
dc.contributor.author | Armenian H | en_US |
dc.contributor.author | Farzadegan H | en_US |
dc.contributor.author | Graham N | en_US |
dc.contributor.author | Mc Arthur J | en_US |
dc.contributor.author | Margolick J.B | en_US |
dc.contributor.author | Palenicek J | en_US |
dc.contributor.author | Muãoz A | en_US |
dc.contributor.author | Hoover D | en_US |
dc.contributor.author | Galai N | en_US |
dc.contributor.author | Jacobson L.P | en_US |
dc.contributor.author | Park L | en_US |
dc.contributor.author | Piantadosi S | en_US |
dc.contributor.author | Su S | en_US |
dc.contributor.author | Phair J.P | en_US |
dc.contributor.author | Bauer K | en_US |
dc.contributor.author | Chmiel J.S | en_US |
dc.contributor.author | Cohen B | en_US |
dc.contributor.author | Variakojis D | en_US |
dc.contributor.author | Wesch J | en_US |
dc.contributor.author | Wolinsky S.M | en_US |
dc.contributor.author | Detels R | en_US |
dc.contributor.author | Visscher B.R | en_US |
dc.contributor.author | Chen I | en_US |
dc.contributor.author | Dudley J | en_US |
dc.contributor.author | Fahey J.L | en_US |
dc.contributor.author | Ferbas J | en_US |
dc.contributor.author | Giorgi J.V | en_US |
dc.contributor.author | Martinez-Maza O | en_US |
dc.contributor.author | Nishanian P | en_US |
dc.contributor.author | Taylor J | en_US |
dc.contributor.author | Zack J | en_US |
dc.contributor.author | Rinaldo C.R | en_US |
dc.contributor.author | Jr | en_US |
dc.contributor.author | Becker J.T | en_US |
dc.contributor.author | Gupta P | en_US |
dc.contributor.author | Ho M | en_US |
dc.contributor.author | Kingsley L | en_US |
dc.contributor.author | Schrager L | en_US |
dc.contributor.author | Kaslow R.A | en_US |
dc.contributor.author | Van Raden M.J | en_US |
dc.contributor.author | Seminara D. | en_US |
dc.creator | Giorgi J.V;Hong-Nerng Ho;Hirji K;Chou C.-C;Hultin L.E;O??Rourke S;Park L;Margolick J.B;Ferbas J;Phair J.P;Saah A.J;Armenian H;Farzadegan H;Graham N;Mc Arthur J;Margolick J.B;Palenicek J;Mu?Oz A;Hoover D;Galai N;Jacobson L.P;Park L;Piantadosi S;Su S;Phair J.P;Bauer K;Chmiel J.S;Cohen B;Variakojis D;Wesch J;Wolinsky S.M;Detels R;Visscher B.R;Chen I;Dudley J;Fahey J.L;Ferbas J;Giorgi J.V;Martinez-Maza O;Nishanian P;Taylor J;Zack J;Rinaldo C.R;Jr;Becker J.T;Gupta P;Ho M;Kingsley L;Schrager L;Kaslow R.A;Van Raden M.J;Seminara D. | - |
dc.date.accessioned | 2020-02-17T07:44:14Z | - |
dc.date.available | 2020-02-17T07:44:14Z | - |
dc.date.issued | 1994 | - |
dc.identifier.issn | 0022-1899 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/460198 | - |
dc.description.abstract | Subsets of activated CD8+ lymphocytes defined by membrane expression of the activation antigens HLA-DR and CD38 were counted by three-color flow cytometry in homosexual men who subsequently became seropositive for human immunodeficiency virus type 1 (HIV). Profound CD8+ cell activation was seen in all subjects at seroconversion and 6 and 12 months later. The HLA-DR+ CD38+ CD8+ cell population, which has potent direct HIV cytotoxic T cell activity, was markedly elevated at seroconversion in all subjects. In some men, these levels remained elevated throughout the first year of infection. During the next 5 years, these men had stable CD4+ cell levels, whereas the others did not. Long-term survivors (seropositive for 9 years, >800 CD4+ cells/mm3) also had elevated levels of this subset, despite few other activated CD8+ cells. Thus, selective elevation of HLA-DR+ CD38 CD8+ cells was a marker of subsequent stable HIV disease. ? 1994 by The University of Chicago. | en_US |
dc.relation.ispartof | Journal of Infectious Diseases | en_US |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | cd38 antigen; cd4 antigen; cd8 antigen; HLA DR antigen; lymphocyte antigen; adult; article; clinical article; controlled study; cytotoxic t lymphocyte; flow cytometry; helper cell; homosexuality; human; human cell; human immunodeficiency virus 1; human immunodeficiency virus infection; lymphocyte activation; male; priority journal; seroconversion; suppressor cell; Antigens, CD; Antigens, Differentiation; Bisexuality; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Flow Cytometry; Follow-Up Studies; HIV Seronegativity; HIV Seropositivity; HLA-DR Antigens; Homosexuality, Male; Human; Lymphocyte Activation; Male; Predictive Value of Tests; Reference Values; Support, U.S. Gov't, P.H.S.; Survival Analysis; T-Lymphocyte Subsets; Time Factors | - |
dc.title | Cd8+ lymphocyte activation at human immunodeficiency virus type 1 seroconversion: Development of Hla-Dr+ Cd38 Cd8+ cells is associated with subsequent stable Cd4+ cell levels | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1093/infdis/170.4.775 | - |
dc.identifier.pmid | 7930717 | - |
dc.identifier.scopus | 2-s2.0-0027965585 | - |
dc.relation.pages | 775-781 | en_US |
dc.relation.journalvolume | 170 | en_US |
dc.relation.journalissue | 4 | en_US |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
crisitem.author.dept | Obstetrics & Gynecology | - |
crisitem.author.dept | Obstetrics & Gynecology-NTUH | - |
crisitem.author.orcid | 0000-0002-7207-0089 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 醫學系 |
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