https://scholars.lib.ntu.edu.tw/handle/123456789/460292
DC 欄位 | 值 | 語言 |
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dc.contributor.author | Obruca, Andreas | en_US |
dc.contributor.author | Schenk, Michael | en_US |
dc.contributor.author | Tews, Gernot | en_US |
dc.contributor.author | Mardešić, Tonko | en_US |
dc.contributor.author | Mrázek, Milan | en_US |
dc.contributor.author | Meinertz, Helle | en_US |
dc.contributor.author | Hedon, Bernard | en_US |
dc.contributor.author | Barrière, Paul | en_US |
dc.contributor.author | Kim, Chunghoon | en_US |
dc.contributor.author | Koong, Mikyoung | en_US |
dc.contributor.author | Yoon, Taeki | en_US |
dc.contributor.author | Koziol, Katarzyna | en_US |
dc.contributor.author | Kuczynski, Waldemar | en_US |
dc.contributor.author | Bernabeu, Rafael | en_US |
dc.contributor.author | Ruiz Balda, Jose Antonio | en_US |
dc.contributor.author | Bergh, Christina | en_US |
dc.contributor.author | Hillensjö, Torbjörn | en_US |
dc.contributor.author | Huang, Hong-Yuan | en_US |
dc.contributor.author | YU-SHIH YANG | en_US |
dc.contributor.author | Mauw, Ellemiek Von | en_US |
dc.contributor.author | Elbers, Jolanda | en_US |
dc.contributor.author | Witjes, Han | en_US |
dc.contributor.author | Zandvliet, Anthe S | en_US |
dc.contributor.author | Mannaerts, Bernadette | en_US |
dc.creator | Mannaerts B.;Zandvliet A.S;Witjes H;Elbers J;Mauw E.V;YU-SHIH YANG;Huang H.-Y;Hillensj? T;Bergh C;Ruiz Balda J.A;Bernabeu R;Kuczynski W;Koziol K;Yoon T;Koong M;Kim C;Barri?re P;Hedon B;Meinertz H;Mr?zek M;Marde?i? T;Tews G;Schenk M;Obruca A | - |
dc.date.accessioned | 2020-02-17T08:07:09Z | - |
dc.date.available | 2020-02-17T08:07:09Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 1472-6483 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/460292 | - |
dc.description.abstract | In this double-blind, double-dummy, randomized, equivalence trial (Ensure), 396 women weighing 60 kg or less who underwent controlled ovarian stimulation prior to IVF or intracytoplasmic sperm injection were randomized in a 2:1 ratio to a single dose of 100 μg corifollitropin alfa or daily 150 IU recombinant FSH (rFSH) for the first 7 days of stimulation in a gonadotrophin-releasing hormone antagonist protocol. The mean ± SD number of oocytes retrieved per started cycle was 13.3 ± 7.3 for corifollitropin alfa versus 10.6 ± 5.9 for rFSH. The estimated treatment difference of +2.5 oocytes (95% CI 1.2-3.9) in favour of corifollitropin alfa (P < 0.001) was well within the predefined equivalence margin. The median (range) duration of stimulation was 9 (6-15) days in both groups. In 32.8% of the patients, one injection of corifollitropin alfa was sufficient to reach the human chorionic gonadotrophin criterion. The incidence of moderate and severe ovarian hyperstimulation syndrome was 3.4% for corifollitropin alfa and 1.6% for rFSH. A dose of 100 μg corifollitropin alfa offers a simplified treatment option for potential normal responder patients with a lower body weight. ? 2010, Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved. | en_US |
dc.relation.ispartof | Reproductive BioMedicine Online | en_US |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | chorionic gonadotropin; corifollitropin alfa; fertility promoting agent; follistim pen; ganirelix; gonadorelin antagonist; placebo; progesterone; recombinant follitropin; recombinant hormone; unclassified drug; adult; antepartum hemorrhage; article; body weight; clinical protocol; clinical trial; controlled clinical trial; controlled study; double blind procedure; drug blood level; drug dose increase; drug dose reduction; drug efficacy; drug elimination; drug half life; drug hypersensitivity; drug induced headache; drug safety; ectopic pregnancy; embryo transfer; female; female infertility; fertilization in vitro; hormonal regulation; hormonal therapy; human; injection; injection site reaction; intracytoplasmic sperm injection; major clinical study; menstrual cycle; multicenter study; oocyte; oocyte retrieval; ovarian stimulation; ovary hyperstimulation; pelvic discomfort; pelvis pain syndrome; randomized controlled trial; single drug dose; time to maximum plasma concentration; treatment duration; treatment outcome | - |
dc.title | Corifollitropin alfa for ovarian stimulation in IVF: A randomized trial in lower-body-weight women | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1016/j.rbmo.2010.03.019 | - |
dc.identifier.pmid | 20483664 | - |
dc.identifier.scopus | 2-s2.0-78650171808 | - |
dc.relation.pages | 66-76 | en_US |
dc.relation.journalvolume | 21 | en_US |
dc.relation.journalissue | 1 | en_US |
item.fulltext | no fulltext | - |
item.openairetype | journal article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | Obstetrics & Gynecology | - |
crisitem.author.dept | Obstetrics & Gynecology-NTUH | - |
crisitem.author.orcid | 0000-0002-8633-0873 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 醫學系 |
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