https://scholars.lib.ntu.edu.tw/handle/123456789/460300
Title: | Effectiveness of cetrorelix for the prevention of premature luteinizing hormone surge during controlled ovarian stimulation using letrozole and gonadotropins: a randomized trial | Authors: | Lee T.-H Lin Y.-H Seow K.-M Hwang J.-L Tzeng C.-R YU-SHIH YANG |
Issue Date: | 2008 | Journal Volume: | 90 | Journal Issue: | 1 | Start page/Pages: | 113-120 | Source: | Fertility and Sterility | Abstract: | Objective: To evaluate the effectiveness of a GnRH antagonist in preventing premature LH surge under a letrozole and gonadotropin protocol. Design: Prospective, randomized clinical trial. Setting: A teaching hospital and tertiary medical center. Patient(s): Sixty-one patients were randomly assigned into two letrozole and gonadotropin-treated groups. These were distinguished by the absence (group I) or presence (group II) of supplementation with 0.25 mg of cetrorelix. Intervention(s): Controlled ovarian stimulation with letrozole and gonadotropins, cetrorelix and intrauterine insemination. Main Outcome Measure(s): Rate of premature LH surge. Result(s): Compared with group I, the rate of premature LH surge was statistically significantly lower for group II (43.4% [13/30] vs. 19.4% [6/31]), but the amount of gonadotropins used was statistically significantly higher (817.5 ± 28.5 vs. 907.5 ± 27.3 IU). Patients with premature LH surge had a statistically significantly lower pregnancy rate (21.4% [9/42] vs. 0 [0/18]) relative to their unaffected counterparts. Conclusion(s): A flexible protocol of 0.25 mg of cetrorelix for IUI cycles appears to suppress the rate of premature LH surge during ovarian stimulation with letrozole and gonadotropins. However, the incidence of premature LH surge remains too high, and modification will be necessary before the application of cetrorelix to IVF treatment. ? 2008 American Society for Reproductive Medicine. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/460300 | ISSN: | 0015-0282 | DOI: | 10.1016/j.fertnstert.2007.06.029 | SDG/Keyword: | cetrorelix; chorionic gonadotropin; gonadorelin antagonist; gonadotropin derivative; letrozole; luteinizing hormone; recombinant chorionic gonadotropin; recombinant follitropin; adult; article; cell stimulation; clinical trial; controlled clinical trial; controlled study; dose response; drug efficacy; female; female infertility; fertilization in vitro; human; intrauterine insemination; major clinical study; ovary cell culture; pregnancy rate; priority journal; prospective study; randomized controlled trial; statistical significance; university hospital; Adult; Aromatase Inhibitors; Chorionic Gonadotropin; Drug Therapy, Combination; Female; Fertility Agents, Female; Fertilization in Vitro; Follicle Stimulating Hormone; Gonadotropin-Releasing Hormone; Gonadotropins; Hormone Antagonists; Humans; Infertility; Luteinizing Hormone; Nitriles; Ovulation Induction; Pregnancy; Pregnancy Rate; Prospective Studies; Recombinant Proteins; Taiwan; Treatment Outcome; Triazoles; Up-Regulation |
Appears in Collections: | 醫學系 |
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