https://scholars.lib.ntu.edu.tw/handle/123456789/460909
Title: | Effects of menopause and obesity on lipid profiles in middle-aged Taiwanese women: The Chin-Shan Community Cardiovascular Cohort Study | Authors: | PAO-LING TORNG TA-CHEN SU Sung F.C KUO-LIONG CHIEN Huang S.-C SONG-NAN CHOW Lee Y.-T. |
Issue Date: | 2000 | Journal Volume: | 153 | Journal Issue: | 2 | Start page/Pages: | 413-421 | Source: | Atherosclerosis | Abstract: | In this cross-sectional study, we examined the associations between lipid profiles and menopausal status, age, and obesity in Taiwanese women. The study population, established in 1990-91, consisted of 671 premenopausal and 872 postmenopausal women from the Chin-Shan Community Cardiovascular Cohort (CCCC). The associations of age, body mass index (BMI), and menopausal status with serum levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), apoproteins (Apo) A-1 and B, and lipoprotein (a) [Lp (a)] were evaluated. The results showed that menopause was associated with significant increases in TC, LDL-C, TG, and Apo B levels (all P < 0.001). Total cholesterol, LDL-C, TG, and Apo B levels increased consistently with BMI in middle-aged women, regardless of menopausal status. Among women aged 45-49, menopausal women had significantly higher levels of TC and LDL-C than premenopausal women (P < 0.01). However, TG and Apo B levels were higher in postmenopausal than in premenopausal women aged 50-54 years (P < 0.05). Standardized regression analyses showed all lipid variables, except those of Apo A1 and Lp (a) before menopause and TC, LDL-C, and Lp (a) after menopause, were significantly associated with BMI (all P < 0.01). We conclude serum lipid levels in Taiwanese women are no more strongly associated with menopause and BMI than with age. ? 2000 Elsevier Science Ireland Ltd. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/460909 | ISSN: | 0021-9150 | DOI: | 10.1016/S0021-9150(00)00423-8 | SDG/Keyword: | apolipoprotein A1; apolipoprotein B; cholesterol; high density lipoprotein cholesterol; lipoprotein A; low density lipoprotein cholesterol; triacylglycerol; adult; aged; article; body mass; cholesterol blood level; female; human; human cell; human tissue; major clinical study; menopause; obesity; premenopause; priority journal; regression analysis; Taiwan; Adult; Aged; Aging; Cohort Studies; Cross-Sectional Studies; Female; Humans; Lipids; Menopause; Middle Aged; Obesity; Taiwan |
Appears in Collections: | 醫學系 |
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