https://scholars.lib.ntu.edu.tw/handle/123456789/463937
DC 欄位 | 值 | 語言 |
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dc.contributor.author | Tseng, C.-L. | en_US |
dc.contributor.author | Chang, K.-C. | en_US |
dc.contributor.author | Yeh, M.-C. | en_US |
dc.contributor.author | Yang, K.-C. | en_US |
dc.contributor.author | Tang, T.-P. | en_US |
dc.contributor.author | Lin, F.-H. | en_US |
dc.contributor.author | FENG-HUEI LIN | zz |
dc.creator | FENG-HUEI LIN;Lin, F.-H.;Tang, T.-P.;Yang, K.-C.;Yeh, M.-C.;Chang, K.-C.;Tseng, C.-L. | - |
dc.date.accessioned | 2020-02-26T01:32:59Z | - |
dc.date.available | 2020-02-26T01:32:59Z | - |
dc.date.issued | 2014 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/463937 | - |
dc.description.abstract | Lung cancer is a harmful form of cancer; chemotherapy is the main methodology for treating it, despite continuing problems such as severe side effects. For the reduction of side effects, hydroxyapatite (HAP) has been investigated as a drug carrier recently. Moreover, hyperthermia has been reported to be an effective cancer treatment modality. In order to develop an effective agent for lung cancer treatment, dual-functional nanoparticles made from HAP with iron and platinum ions incorporation (Pt-Fe-HAP) were developed for chemo-hyperthermia application. Variant HAP were synthesized and analyzed in this study. The crystallization and chemical composition were examined by X-ray diffraction (XRD) and Fourier transform infrared (FT-IR) spectroscopy. Fe 2+ and Pt2+ content was determined by inductively coupled plasma atomic emission spectroscopy (ICP-AES). The biocompatibility and anticancer effects of Pt-Fe-HAP were assessed using 3T3 cells via a WST-1 assay. The effect of hyperthermia on the treatment of Sprague Dawley (SD) rat fibroblast and human lung adenocarcinoma (A549) cells under a magnetic field was evaluated by a lactate dehydrogenase (LDH) assay. Overall, we have determined Pt-Fe-HAP could be prepared by a co-precipitation method with Fe 2+/Pt2+ incorporation. The platinum and iron contents were 3.69 wt% and 12.20 wt%, respectively. The hysteresis curves showed that the Pt-Fe-HAP possessed ferromagnetic properties at low magnetic fields. The water temperature could be raised to 46 C when the Pt-Fe-HAP suspension was treated in a magnetic field for 6 min. We also confirmed that the extraction solution of Pt-Fe-HAP was nontoxic, but the direct culture of 3T3 cells with these nanoparticles was harmful. Finally, the results of the LDH assay revealed Pt-Fe-HAP was highly toxic to A549 cells after magnetic field treatment under hyperthermia but no damage to fibroblast cells was observed. The magnetic Pt-Fe-HAP nanoparticles show the potential to be a dual agent to treat cancer cells by chemo-hyperthermia therapy. ? 2013 Elsevier Ltd and Techna Group S.r.l. | - |
dc.relation.ispartof | Ceramics International | - |
dc.subject | Chemotherapy; Hydroxyapatite (HAP); Hyperthermia; Magnetic particle; Platinum | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.title | Development of a dual-functional Pt-Fe-HAP magnetic nanoparticles application for chemo-hyperthermia treatment of cancer | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1016/j.ceramint.2013.09.137 | - |
dc.identifier.scopus | 2-s2.0-84895063145 | - |
dc.identifier.url | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84895063145&doi=10.1016%2fj.ceramint.2013.09.137&partnerID=40&md5=c07ab6aa35d9e9d7c8a4e47178764b80 | - |
dc.relation.pages | 5117-5127 | - |
dc.relation.journalvolume | 40 | - |
dc.relation.journalissue | 4 | - |
item.fulltext | no fulltext | - |
item.cerifentitytype | Publications | - |
item.openairetype | journal article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.grantfulltext | none | - |
crisitem.author.dept | Biomedical Engineering | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Engineering | - |
顯示於: | 醫學工程學研究所 |
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