https://scholars.lib.ntu.edu.tw/handle/123456789/465718
標題: | Combined photothermo-chemotherapy using gold nanoshells on drug-loaded micelles for colorectal cancer treatment | 作者: | Lee S.-Y. MING-JIUM SHIEH |
關鍵字: | chemotherapy; colorectal cancer; combined therapy; Gold nanoshells; micelles; photothermal therapy; SN-38 | 公開日期: | 2018 | 出版社: | SPIE | 卷: | 10507 | 來源出版物: | Progress in Biomedical Optics and Imaging - Proceedings of SPIE | 摘要: | Combined photothermo-chemotherapy is a new strategy for cancer treatment which improves the therapeutic outcome by synergistic effects of both therapies. Here, we presented a multifunctional gold nanoshell that exhibited excellent photothermal conversion and delivered the hydrophobic chemotherapy drug, SN-38. The positively charged SN-38-loaded PDMA-PCL micelles were decorated with a gold layer by in situ reduction of chloroauric acid on the surface of micelles. Scanning and transmission electron microscopy images proved micelles were successfully decorated and the resulting gold nanoshells had a spherical morphology with a narrow size distribution. The synthesized gold nanoshells displayed a broad surface plasmon resonance peak in the near-infrared wavelength region and a great photothermal conversion ability. After pegylation, gold nanoshells were stable in biological media and appeared highly biocompatible in the absence of laser irradiation. Upon near-infrared laser irradiation, incident energy was converted into heat by gold nanoshells on SN-38-loaded micelles (SN-38@pGNS), which causes local temperature increase and triggers the release of encapsulated drug. Compared to SN-38, SN-38-loaded micelles, or laser with drug-free gold nanoshells alone, combined photothermo-chemotherapy using SN-38@pGNS with laser irradiation killed colorectal cancer cells with higher efficacy in vitro and demonstrated significant tumor suppression in vivo, suggesting that gold nanoshells on drug-loaded micelles delivered SN-38 and photothermal therapy in synergistic actions and might be a potential candidate for future colorectal cancer therapy. ? COPYRIGHT SPIE. Downloading of the abstract is permitted for personal use only. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85045319284&doi=10.1117%2f12.2287184&partnerID=40&md5=48b4410dff3ddd774bff7f0dcaf9b0a3 https://scholars.lib.ntu.edu.tw/handle/123456789/465718 |
ISSN: | 1605-7422 | DOI: | 10.1117/12.2287184 | SDG/關鍵字: | Biocompatibility; Chemotherapy; Controlled drug delivery; Diseases; Gold; High resolution transmission electron microscopy; Infrared devices; Infrared lasers; Irradiation; Medical applications; Micelles; Nanostructured materials; Scanning electron microscopy; Surface plasmon resonance; Targeted drug delivery; Transmission electron microscopy; Colorectal cancer; Combined therapy; Gold nano-shells; Narrow size distributions; Near-infrared laser irradiation; Photo-thermal conversions; Photothermal therapy; Scanning and transmission electron microscopy; Nanoshells |
顯示於: | 醫學工程學研究所 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。