https://scholars.lib.ntu.edu.tw/handle/123456789/465721
標題: | Photothermal, Targeting, Theranostic Near-Infrared Nanoagent with SN38 against Colorectal Cancer for Chemothermal Therapy | 作者: | Tsai M.-H. Peng C.-L. Yang S.-J. MING-JIUM SHIEH |
關鍵字: | chemothermal therapy; colorectal cancer; cRGD; IR780; SN38 | 公開日期: | 2017 | 出版社: | American Chemical Society | 卷: | 14 | 期: | 8 | 起(迄)頁: | 2766-2780 | 來源出版物: | Molecular Pharmaceutics | 摘要: | Cancer research regarding near-infrared (NIR) agents for chemothermal therapy (CTT) has shown that agents with specific functions are able to inhibit tumor growth. The aim of current study was to optimize CTT efficacy for treatment of colorectal cancer (CRC) by exploring strategies which can localize high temperature within tumors and maximize chemotherapeutic drug uptake. We designed a new and simple multifunctional NIR nanoagent composed of the NIR cyanine dye, polyethylene glycol, and a cyclic arginine-glycine-aspartic acid peptide and loaded with the anti-CRC chemotherapeutic agent, 7-ethyl-10-hydroxy-camptothecin (SN38). Each component of this nanoagent exhibited its specific functions that help boost CTT efficacy. The results showed that this nanoagent greatly strengthens the theranostic effect of SN38 and CTT against CRC due to its NIR imaging ability, photothermal, enhanced permeability and retention (EPR) effect, reticuloendothelial system avoidance, and angiogenic blood vessel-targeting properties. This NIR nanoagent will help facilitate development of new strategies for treating CRC. ? 2017 American Chemical Society. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85027045853&doi=10.1021%2facs.molpharmaceut.7b00315&partnerID=40&md5=05702c18f8dd9c0b808818394c22b079 https://scholars.lib.ntu.edu.tw/handle/123456789/465721 |
ISSN: | 1543-8384 | DOI: | 10.1021/acs.molpharmaceut.7b00315 | SDG/關鍵字: | arginylglycylaspartic acid; cyanine dye; firtecan; macrogol; 2-(2-(2-chloro-3-((1,3-dihydro-3,3-dimethyl-1-propyl-2H-indol-2-ylidene)ethylidene)-1-cyclohexen-1-yl)ethenyl)-3,3-dimethyl-1-propylindolium; antineoplastic agent; camptothecin; indole derivative; irinotecan; nanoparticle; animal experiment; animal model; antineoplastic activity; Article; cancer inhibition; cancer therapy; colorectal cancer; drug absorption; drug release; drug synthesis; drug uptake; female; human; human cell; human cell culture; in vitro study; in vivo study; mouse; near infrared chemothermal therapy; nonhuman; photothermal therapy; priority journal; theranostic nanomedicine; analogs and derivatives; chemistry; colorectal tumor; phototherapy; procedures; theranostic nanomedicine; tumor cell line; Antineoplastic Agents; Camptothecin; Cell Line, Tumor; Colorectal Neoplasms; Humans; Indoles; Nanoparticles; Phototherapy; Theranostic Nanomedicine |
顯示於: | 醫學工程學研究所 |
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