https://scholars.lib.ntu.edu.tw/handle/123456789/465793
標題: | Enhanced Cytotoxicity of Doxorubicin by Micellar Photosensitizer-mediated Photochemical Internalization in Drug-resistant MCF-7 Cells | 作者: | Hsu C.Y. Lai P.S. Pai C.L. MING-JIUM SHIEH Nishiyama N. Kataoka K. |
關鍵字: | Doxorubicin; drug-resistance; micelle; photochemical internalization | 公開日期: | 2009 | 卷: | 23 | 起(迄)頁: | 1451-1454 | 來源出版物: | IFMBE Proceedings | 摘要: | Multiple drug resistance (MDR) is a major clinical problem that seriously reduces the efficacy of many chemotherapy agents. In doxorubicin-resistant breast cancer cells, drugs accumulate only within discrete cytoplasmic organelles and almost none is detectable in the nuclei, the target of anthracycline drugs. Photochemical internalization (PCI), a specific branch of photodynamic therapy, is a novel technology utilized for the site-specific release of macromolecules within cells. In this study, the phototoxicity of dendrimer phthalocyanine (DPc)-encapsulated polymeric micelle (DPc/m) combined with doxorubicin was studied in drug-resistant MCF-7 cells. After photoirradiation with a LED (670 nm), the internalized DPc/m showed unique photochemical processes inside of the cells that can disrupt the endosomal/lysosomal membrane and thereby cause the doxorubicin release from the lysosome to nuclei. In conclusion, DPc/m-mediated PCI destroyed endosomal/ lysosomal membrane efficiently that can reverse the MDR phenotype of doxorubicin resistant MCF-7 cells. The technique is a promising new approach to overcome the drugresistance in breast cancer cells. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84872830160&doi=10.1007%2f978-3-540-92841-6_358&partnerID=40&md5=f64ff9327af5051dd08023ac0396b8a9 https://scholars.lib.ntu.edu.tw/handle/123456789/465793 |
ISSN: | 1680-0737 | DOI: | 10.1007/978-3-540-92841-6_358 | SDG/關鍵字: | Anthracycline drugs; Dendrimer phthalocyanine; Doxorubicin; Drug-resistance; Lysosomal membranes; Multiple drug resistance; Photochemical internalization; Photochemical process; Biomedical engineering; Catalyst activity; Cytology; Drug therapy; Micelles; Photodynamic therapy; Photosensitizers; Cells |
顯示於: | 醫學工程學研究所 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。