https://scholars.lib.ntu.edu.tw/handle/123456789/465821
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Wang H.-H. | en_US |
dc.contributor.author | MING-JIUM SHIEH | en_US |
dc.contributor.author | Liao K.-F. | en_US |
dc.creator | Wang H.-H.;Ming-Jium Shieh;Liao K.-F. | - |
dc.date.accessioned | 2020-02-27T06:39:46Z | - |
dc.date.available | 2020-02-27T06:39:46Z | - |
dc.date.issued | 2005 | - |
dc.identifier.issn | 1007-9327 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-16344362645&doi=10.3748%2fwjg.v11.i10.1540&partnerID=40&md5=9db9cae6c6a3254d0004b98cfc85dc26 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/465821 | - |
dc.description.abstract | Aim: Racecadotril is a specific enkephalinase inhibitor that exhibits intestinal antisecretory activity without affecting intestinal transit. Loperamide is an effective anti-diarrheal agent, but it usually induces constipation. This study is to compare the efficacy, safety, and tolerability of racecadotril versus loperamide in the outpatient treatment of acute diarrhea in adults. Methods: A two-center, randomized, parallel-group, single-blind study was carried out to compare the efficacy, tolerability, and safety of racecadotril (100 mg thrics daily) and loperamide (2.0 mg 2 twics daily) in 62 adult patients suffering from acute diarrhea. The main efficacy criterion used was the duration of diarrhea after beginning the treatment (in hours). Other signs and symptoms were also evaluated. Results: The clinical success rates for these anti-diarrheal treatments were 95.7% and 92.0% for racecadotril and loperamide respectively. Patients on racecadotril had a median duration of diarrhea of 19.5 h compared with a median of 13 h for patients on loperamide. Rapid improvement in anal burn and nausea was found for each drug. However, more patients on loperamide suffered from reactive constipation (29.0% vs 12.9%). Itching, another adverse event was notably higher in the racecadotril group (28.6% vs 0%). With regard to other adverse events, the two medications showed similar occurrence rates and similar concomitant medication usage rates. Conclusion: Racecadotril and loperamide are rapid, equally effective treatments for acute diarrhea in adults, but loperamide treatment is associated with a higher incidence of treatment-related constipation. ? 2005 The WJG Press and Elsevier Inc. All rights reserved. | - |
dc.publisher | WJG Press | - |
dc.relation.ispartof | World Journal of Gastroenterology | - |
dc.subject | Acute diarrhea; Loperamide; Racecadotril | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | acetorphan; antidiarrheal agent; enkephalinase inhibitor; loperamide; membrane metalloendopeptidase; abdominal pain; acute diarrhea; adult; article; clinical trial; constipation; controlled clinical trial; controlled study; disease control; disease duration; drug dose regimen; drug efficacy; drug mechanism; drug safety; drug tolerability; female; human; intestine function; intestine transit time; major clinical study; male; multicenter study; nausea; outpatient care; pruritus; randomized controlled trial; single blind procedure; treatment outcome | - |
dc.title | A blind, randomized comparison of racecadotril and loperamide for stopping acute diarrhea in adults | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.3748/wjg.v11.i10.1540 | - |
dc.identifier.scopus | 2-s2.0-16344362645 | - |
dc.relation.pages | 1540-1543 | - |
dc.relation.journalvolume | 11 | - |
dc.relation.journalissue | 10 | - |
item.fulltext | no fulltext | - |
item.openairetype | journal article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | Biomedical Engineering | - |
crisitem.author.dept | Oncology-NTUH | - |
crisitem.author.dept | School of Medicine | - |
crisitem.author.orcid | 0000-0003-2921-4443 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Engineering | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
顯示於: | 醫學工程學研究所 |
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