https://scholars.lib.ntu.edu.tw/handle/123456789/465980
Title: | Involvement of 14-3-3γ overexpression in extrahepatic metastasis of hepatocellular carcinoma | Authors: | BOR-SHENG KO I-RUE LAI Chang T.-C. Liu T.-A. Chen S.-C. Wang J. Jan Y.-J. Liou J.-Y. |
Issue Date: | 2011 | Journal Volume: | 42 | Journal Issue: | 1 | Start page/Pages: | 129-135 | Source: | Human Pathology | Abstract: | The 14-3-3γ protein is an important regulator of various cellular and physiologic functions. Overexpression promotes cell proliferation and induces cancer cell polyploidization. Production is up-regulated in human hepatocellular carcinoma. However, the clinical significance of 14-3-3γ for human hepatocellular carcinoma metastasis and survival has not been clarified. In this study, 55 patients with human hepatocellular carcinoma were enrolled; and 18 of them were identified as having extrahepatic metastases. Expression of 14-3-3γ in these primary and metastatic samples was measured with semiquantitative immunohistochemistry analysis. Overexpression of 14-3-3γ was observed in 38 (69.1%) of the primary tumors, correlated significantly with a high α-fetoprotein concentration (P = .003), and predicted a higher probability of extrahepatic metastasis (cumulative probabilities at 5 years: 42.2% ± 8.0% versus 5.9% ± 5.7%, 14-3-3γ positive versus negative; P = .012). Furthermore, 14-3-3γ overexpression was associated with a worse 5-year overall survival rate (81.6% ± 9.6% versus 59.5% ± 8.1%, respectively) and a worse 5-year progression-free survival rate (75.6% ± 10.6% versus 48.6% ± 8.2%, respectively). Elevated expression of 14-3-3γ in human hepatocellular carcinoma predicts extrahepatic metastasis and worse survival. The protein thus is a candidate biomarker and a potential target for novel therapies against human hepatocellular carcinoma progression and metastasis. ? 2011 Elsevier Inc. All rights reserved. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-78650001931&doi=10.1016%2fj.humpath.2010.01.028&partnerID=40&md5=a98779749b23d223988b8ef76ee5b059 https://scholars.lib.ntu.edu.tw/handle/123456789/465980 |
ISSN: | 0046-8177 | DOI: | 10.1016/j.humpath.2010.01.028 | SDG/Keyword: | alpha fetoprotein; biological marker; protein 14 3 3; protein 14 3 3gamma; unclassified drug; adult; article; cancer survival; controlled study; female; human; immunohistochemistry; liver cell carcinoma; major clinical study; male; metastasis; overall survival; prediction; probability; progression free survival; protein expression; survival rate; 14-3-3 Proteins; Carcinoma, Hepatocellular; Female; Humans; Liver Neoplasms; Male; Middle Aged; Neoplasm Metastasis; Prognosis; Survival Rate |
Appears in Collections: | 解剖學暨細胞生物學科所 |
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