https://scholars.lib.ntu.edu.tw/handle/123456789/467870
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | SUNG-CHUN TANG | en_US |
dc.contributor.author | Chen Y.-R. | en_US |
dc.contributor.author | Chi N.-F. | en_US |
dc.contributor.author | CHIH-HAO CHEN | en_US |
dc.contributor.author | Cheng Y.-W. | en_US |
dc.contributor.author | Hsieh F.-I. | en_US |
dc.contributor.author | Hsieh Y.-C. | en_US |
dc.contributor.author | Yeh H.-L. | en_US |
dc.contributor.author | Sung P.-S. | en_US |
dc.contributor.author | Hu C.-J. | en_US |
dc.contributor.author | Chern C.-M. | en_US |
dc.contributor.author | Lin H.-J. | en_US |
dc.contributor.author | Lien L.-M. | en_US |
dc.contributor.author | Peng G.-S. | en_US |
dc.contributor.author | Chiou H.-Y. | en_US |
dc.contributor.author | JIANN-SHING JENG | en_US |
dc.creator | SUNG-CHUN TANG;Jeng J.-S.;Chiou H.-Y;Peng G.-S;Lien L.-M;Lin H.-J;Chern C.-M;Hu C.-J;Sung P.-S;Yeh H.-L;Hsieh Y.-C;Hsieh F.-I;Cheng Y.-W;Chen C.-H;Chi N.-F;Chen Y.-R | - |
dc.date.accessioned | 2020-03-02T12:10:42Z | - |
dc.date.available | 2020-03-02T12:10:42Z | - |
dc.date.issued | 2019-01 | - |
dc.identifier.issn | 2328-9503 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/467870 | - |
dc.description.abstract | Objective: Features of cerebral autosomal dominant arteriopathy with subcortical infarct and leukoencephalopathy (CADASIL) caused by NOTCH3 mutations vary between ethnicities and regions. In Taiwan, more than 70% of CADASIL patients carry the mutation hot spot of p.R544C. We investigated the prevalence of NOTCH3 p.R544C mutation in stroke patients in Taiwan. Methods: This prospective, multicenter study recruited acute stroke patients within 10?days of symptom onset. The p.R544C mutation was identified by polymerase chain reaction with confronting two-pair primers and sequencing. Clinical parameters, vascular risk factors, stroke subtypes, and stroke outcomes were analyzed. Results: Of the 1970 stroke patients (mean age 61.1?±?13.6?years, male 69.5%) included, 1705 (86.5%) had ischemic stroke and 265 (13.5%) had intracerebral hemorrhage. The prevalence of p.R544C in the study population was 2.8% (95% confidence interval [CI]?=?2.1–3.5%). The prevalence was highest in patients with small vessel occlusion type of ischemic stroke (5.6%), followed by intracerebral hemorrhage (5.3%), and infarct of undetermined etiology (2.7%), and was low in patients with cardioembolism (0.8%) and large artery atherosclerosis (0.7%). All p.R544C patients with intracerebral hemorrhage were nonlobar hemorrhage. Sibling history of stroke (odds ratio [OR]?=?4.50, 95% CI?=?1.67–12.14 in ischemic stroke; OR?=?6.03, 95% CI?=?1.03–35.47 in intracerebral hemorrhage, respectively) and small vessel occlusion (OR, 4.03, 95% CI, 1.26–12.92) were significantly associated with p.R544C. Interpretation: p.R544C NOTCH3 mutation is underdiagnosed in stroke patients in Taiwan, especially in those with small vessel occlusion and sibling history of stroke. ? 2018 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association. | en_US |
dc.relation.ispartof | Annals of Clinical and Translational Neurology | en_US |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | genomic DNA; Notch3 receptor; adult; Article; blood vessel occlusion; brain atherosclerosis; brain hemorrhage; brain ischemia; brain stem; CADASIL; cardioembolism; cerebellum; clinical assessment; cohort analysis; computer assisted tomography; coronary artery atherosclerosis; DNA extraction; embolism; female; gene; gene mutation; genotype; human; hypertension; major clinical study; male; middle aged; multicenter study; National Institutes of Health Stroke Scale; NOTCH3 gene; nuclear magnetic resonance imaging; outcome assessment; polymerase chain reaction; prevalence; prospective study; risk factor; stroke patient; thalamus; thromboembolism | - |
dc.title | Prevalence and clinical characteristics of stroke patients with p.R544C NOTCH3 mutation in Taiwan | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1002/acn3.690 | - |
dc.identifier.scopus | 2-s2.0-85056765275 | - |
dc.relation.pages | 121 | en_US |
dc.relation.journalvolume | 6 | en_US |
dc.relation.journalissue | 1 | en_US |
dc.relation.pageend | 128 | en_US |
item.fulltext | no fulltext | - |
item.openairetype | journal article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | Neurology-NTUH | - |
crisitem.author.dept | Neurology | - |
crisitem.author.dept | Neurology-NTUH | - |
crisitem.author.dept | Neurology | - |
crisitem.author.dept | Neurology-NTUH | - |
crisitem.author.dept | Neurology | - |
crisitem.author.orcid | 0000-0003-3731-5973 | - |
crisitem.author.orcid | 0000-0002-1258-8775 | - |
crisitem.author.orcid | 0000-0002-1456-3686 | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
顯示於: | 醫學系 |
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