https://scholars.lib.ntu.edu.tw/handle/123456789/468525
Title: | Salvianolic acid B inhibits low-density lipoprotein oxidation and neointimal hyperplasia in endothelium-denuded hypercholesterolaemic rabbits | Authors: | Yang T.-L. Lin F.-Y. Chen Y.-H. Chiu J.-J. Shiao M.-S. Tsai C.-S. Lin S.-J. YUH-LIEN CHEN |
Issue Date: | 2011 | Journal Volume: | 91 | Journal Issue: | 1 | Start page/Pages: | 134-141 | Source: | Journal of the Science of Food and Agriculture | Abstract: | BACKGROUND: Atherosclerosis and restenosis are inflammatory responses involving free radicals and lipid peroxidation and may be prevented/cured by antioxidant-mediated lipid peroxidation inhibition. Salvianolic acid (Sal B), a water-soluble antioxidant obtained from a Chinese medicinal herb, is believed to have multiple preventive and therapeutic effects against human vascular diseases. In this study the in vitro and in vivo inhibitory effects of Sal B on oxidative stress were determined.RESULTS: In human aortic endothelial cells (HAECs), Sal B reduced oxidative stress, inhibited low-density lipoprotein (LDL) oxidation and reduced oxidised LDL-induced cytotoxicity. Sal B inhibited Cu2+-induced LDL oxidation in vitro (with a potency 16.3 times that of probucol) and attenuated HAEC-mediated LDL oxidation as well as reactive oxygen species (ROS) production. In cholesterol-fed New Zealand White rabbits (with probucol as positive control), Sal B intake reduced Cu2+-induced LDL oxidation, lipid deposition in the thoracic aorta, intimal thickness of the aortic arch and thoracic aorta and neointimal formation in the abdominal aorta.CONCLUSION: The data obtained in this study suggest that Sal B protects HAECs from oxidative injury-mediated cell death via inhibition of ROS production. The antioxidant activity of Sal B may help explain its efficacy in the treatment of vascular diseases. ? 2010 Society of Chemical Industry. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-78649408796&doi=10.1002%2fjsfa.4163&partnerID=40&md5=cc3c3f1708a80689d16b182a9ea73c31 https://scholars.lib.ntu.edu.tw/handle/123456789/468525 |
ISSN: | 0022-5142 | DOI: | 10.1002/jsfa.4163 | SDG/Keyword: | antioxidant; benzofuran derivative; copper; herbaceous agent; low density lipoprotein; reactive oxygen metabolite; salvianolic acid B; animal; aorta; article; chemistry; cholesterol intake; cytology; drug effect; endothelium cell; human; hypercholesterolemia; hyperplasia; intima; lipid metabolism; lipid peroxidation; metabolism; oxidative stress; pathology; phytotherapy; rabbit; Salvia miltiorrhiza; vascular disease; Animals; Antioxidants; Aorta; Benzofurans; Cholesterol, Dietary; Copper; Drugs, Chinese Herbal; Endothelial Cells; Humans; Hypercholesterolemia; Hyperplasia; Lipid Metabolism; Lipid Peroxidation; Lipoproteins, LDL; Oxidative Stress; Phytotherapy; Rabbits; Reactive Oxygen Species; Salvia miltiorrhiza; Tunica Intima; Vascular Diseases; Oryctolagus cuniculus |
Appears in Collections: | 解剖學暨細胞生物學科所 |
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