https://scholars.lib.ntu.edu.tw/handle/123456789/468714
標題: | Altered cortical structures and tract integrity of the mirror neuron system in association with symptoms of schizophrenia | 作者: | Tseng C.E.J. YI-LING CHIEN CHIH-MIN LIU Wang H.L.S. HAI-GWO HWU WEN-YIH TSENG |
公開日期: | 2015 | 出版社: | Elsevier Ireland Ltd | 卷: | 231 | 期: | 3 | 起(迄)頁: | 286-291 | 來源出版物: | Psychiatry Research - Neuroimaging | 摘要: | The mirror neuron system (MNS) may be implicated in schizophrenia. This study investigated MNS structures, including the pars opercularis (Pop), the supramarginal gyrus (SMg), the third branch of the superior longitudinal fasciculus, and callosal fibers interconnecting bilateral Pop (CC-Pop) and SMg (CC-SMg), and clarified their relationships with positive and negative symptoms of schizophrenia. Participants comprised 32 schizophrenia patients and 32 matched controls who received T1-weighted structural magnetic resonance imaging (MRI, T1WI) and diffusion spectrum imaging (DSI). The cortical measures were computed from the T1WI data. Tract integrity was assessed using a tractography-based analysis of the generalized fractional anisotropy (GFA) derived from the DSI data. Pearson[U+05F3]s correlations and multiple linear regression analysis were used to investigate the associations between MNS structures and positive and negative symptom scores of schizophrenia. Cortical thickness in bilateral Pop and SMg were significantly thinner and mean GFA of CC-Pop was significantly decreased in patients. Negative symptoms were significantly correlated with left SMg volume, and positive symptoms were significantly correlated with right SMg thickness. Multiple linear regression analysis showed left SMg volume to be the strongest contributor to the negative symptoms. The association between left SMg volume and negative symptoms may reflect the degree of social cognition impairment in schizophrenia. ? 2015 Elsevier Ireland Ltd. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84930381694&doi=10.1016%2fj.pscychresns.2015.01.010&partnerID=40&md5=b1ddb05fe3b44abbf4e9906047892d53 https://scholars.lib.ntu.edu.tw/handle/123456789/468714 |
ISSN: | 0925-4927 | DOI: | 10.1016/j.pscychresns.2015.01.010 | SDG/關鍵字: | amisulpride; aripiprazole; clozapine; neuroleptic agent; olanzapine; paliperidone; risperidone; sulpiride; trifluoperazine; adult; anterior commissure; Article; brain cortex; brain size; clinical article; controlled study; cortical thickness (brain); diffusion spectrum imaging; diffusion weighted imaging; disease association; disease duration; disease severity; female; fractional anisotropy; human; inferior frontal gyrus; inferior parietal lobule; male; mirror neuron; negative syndrome; neuroimaging; nuclear magnetic resonance imaging; nuclear magnetic resonance scanner; onset age; pars opercularis; Positive and Negative Syndrome Scale; positive syndrome; posterior commissure; priority journal; schizophrenia; social cognition; superior longitudinal fasciculus; supramarginal gyrus; surface area; tissue structure; tractography; adolescent; diffusion tensor imaging; parietal lobe; pathology; pathophysiology; prefrontal cortex; procedures; schizophrenia; young adult; Adolescent; Adult; Diffusion Tensor Imaging; Female; Humans; Male; Mirror Neurons; Parietal Lobe; Prefrontal Cortex; Schizophrenia; Young Adult |
顯示於: | 醫療器材與醫學影像研究所 |
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