https://scholars.lib.ntu.edu.tw/handle/123456789/468760
標題: | White matter tracts in fronto-striato-thalamic circuit in the human brain: Adiffusion spectrum imaging study | 作者: | Lo Y.-C. Jaw F.-S. Huang S.-C. Yeh Y.-Y. WEN-YIH TSENG |
公開日期: | 2011 | 卷: | 23 | 期: | 3 | 起(迄)頁: | 215-222 | 來源出版物: | Biomedical Engineering - Applications, Basis and Communications | 摘要: | Gender and handedness differences in cognitive functions and brain structures are well recognized. Recent research has reported different white matter structures between male and female subjects. Yet it is unknown whether the gender and handedness effects on different white matter tracts are comparable or disparate. In this study, we focus on three main tracts in the fronto-striato-thalamic circuit, namely, the cingulum bundles (CG), fornices (FXs) and anterior thalamic radiations (ATR). These are the primary connections among the frontal lobe, the limbic system, and the thalamus, integrating functions of emotion control, memory, and decision-making. A total of 40 healthy adults were recruited in this study. There was no significant difference in demographic variables between males and females. Images were acquired on a 3-T Magnetic resonance imaging (MRI) system with an eight-channel head coil. The diffusion spectrum imaging (DSI) experiment was performed by applying 203 diffusion gradient vectors. DSI maps the angular distribution of water molecule displacement by acquiring diffusion MR signals in a more comprehensive way. The theory of DSI is based on the Fourier transform relationship between diffusion MR signals and the average propagator of water molecule displacement. Isotropic spatial resolution was obtained by setting both in-plane and through-plane resolutions as 2.7 mm. A total of 45 trans-axial slices were acquired encompassing the whole brain. DSI analysis was computed based on the Fourier relationship between diffusion echo signals and the probability density function (PDF). Fiber tracking was used to define the targeted tracts. All fiber orientations of the nearest voxels were used to decide the proceeding orientation for the next step. Tracking stopped if there was no coinciding orientation in the nearest voxels. Mean path analysis, a method that projected the anisotropy of PDF [generalized fractional anisotropy (GFA)] onto a single mean path of the specific white matter tract bundle, was used to analyze subtle changes in microstructure coherence along individual tract bundles. The asymmetric differences of targeted tracts were assessed statistically by calculating GFA values and lateralization indices (LIs). The handedness factor of the LI values in CG and ATR showed a trend for significance. The gender factor of the LI values was investigated in FX also. Different white matter tract bundles manifested different degrees of gender effect on GFA distributions. Our results suggest that the gender and handedness factors should be considered when one evaluates the impairment of the fronto-striato-thalamic circuit. ? 2011 National Taiwan University. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-79959988377&doi=10.4015%2fS1016237211002542&partnerID=40&md5=d0866bdf3697939018b905eccede2936 https://scholars.lib.ntu.edu.tw/handle/123456789/468760 |
ISSN: | 1016-2372 | DOI: | 10.4015/S1016237211002542 | SDG/關鍵字: | Anterior thalamic radiation; Cingulum bundles; Diffusion spectrum imaging; Fornix; Gender; Handedness; Angular distribution; Anisotropy; Brain; Decision making; Diffusion; Fourier transforms; Image segmentation; Molecules; Probability density function; Regression analysis; Resonance; Shear deformation; Spectrum analysis; Magnetic resonance imaging; water; adult; anterior thalamic radiation; article; brain fornix; cingulum bundle; diffusion spectrum imaging; diffusion weighted imaging; female; Fourier transformation; fractional anisotropy; human; human experiment; left handedness; limbic system; male; nerve tract; neuroimaging; normal human; nuclear magnetic resonance imaging; right handedness; signal processing; voxel based morphometry; white matter |
顯示於: | 醫療器材與醫學影像研究所 |
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